Assay for collagen degradation

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

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Details

435 79, 435 792, 435 794, 435975, 436518, 436531, G01N 3353

Patent

active

060108630

ABSTRACT:
The patent application describes a sandwich-type immunoassay for the detection and/or quantitation of collagen degradation products in biological samples such as blood, serum, plasma, sputum and cell cultures. The immunoassay uses a first antibody directed at an epitope present on a collagen molecule at a distance of up to 165 amino acids from a collagen telopeptide crosslink site, and a second antibody directed at another epitope of the crosslinked collagen molecule.

REFERENCES:
patent: 5532169 (1996-07-01), Eyre

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