Assay for cardiac troponin I

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 793, 435 794, 435 795, 435975, 436518, 436531, 436811, 436808, 530326, 53038885, 5303891, G01N 3353

Patent

active

058342206

ABSTRACT:
An assay, and kit, for the quantitation of cardiac troponin I in human biological fluid is provided. The assay involves a sandwich assay employing an antibody specific for cardiac troponin I as one binding partner for cardiac troponin I and troponin C as the other binding partner for cardiac troponin I.

REFERENCES:
patent: 4614712 (1986-09-01), Baldwin et al.
patent: 4912033 (1990-03-01), Ladenson et al.
patent: 5290678 (1994-03-01), Jackowski
Syska et al. "A New Method of Preparation of Troponin I (Inhibitory Protein) Using Affinity Chromatography. Evidence for Three Different Forms of Troponin I in Striated Muscle" FEBS Letters (1974) 40(2):253-257.
Potter "Preparation of Troponin and its Subnits" Methods in Enzymology (1982) 85:241-263.
Cummins et al. "Cardiac-specific troponin-I radioimmunoassay in the diagnosis of acute myocardial infarction" Amer. Heart J. (1987) 113(6) 1333-1344.
Bodor et al. "Development of Monoclonal Antibodies for an Assay of Cardiac Troponin-I and Preliminary Results in Suspected Cases of Myocardial Infarction" Clin. Chem. (1992) 38(11):2203-2214.
Jha et al., "Photo-Cross-Linking of Rabbit Skeletal Troponin-I Deletion Mutants with Troponin C. . . " Biochemistry 35:11026-11035, (1996).
K. Armour et al. "Cloning and expression in E. coli of the cDNA encoding human cardiac Troponin I", Gene 131 (1993) 287-292.
G. Bador et al. "Development of Monoclonal Antibodies for an Assay of Cardiac Troponin I. . . ", Clinical Chemistry 38 (1992) 2203-2214.
C. Larue et al, "New Monoclonal Antibodies as Probes for Human Cardiac Troponin I: Epitopic Analykis with Synthetic Peptides", Molecular Immunol. 29(1992)271-8.
C. Larue et al, "Cardiac Specific Immunoenzymometric Assay of Troponin I in. . . Myocardial Infarction", Clinical Chemistry 39(1993)972-979.
International Search Report issued during prosecution of PCT US94/05468 and completed Oct. 7, 1994.
Vallins, W.J., et al., (1990) "Molecular cloning of human cardiac troponin-I using polymerase chain reaction", FEBS, vol. 270, No. 1,2, pp. 57-61.
Cummins, B., and Cummins, P., (1987) "Cardiac Specific Troponin-I Release in Canine Experimental Myocardial Infraction: Development of a Sensitive Enzyme-linked Immunoassay", J. Mol. Cell Cardiol., vol. 19, 999-1010.
Cummins, B., and Cummins, P., (1987) "Immunoassay of the cardiac-specific isoform of troponin-I in the diagnosis of heart muscle damage", Biochemical Society Transactions, vol. 15, Part 6, pp. 1060-1061.
Wilkinson, J.M. and Grand, R.J.A., (1978) "Comparison of amino acid sequence of troponin I from different striated muscles", Nature, vol. 271, pp. 31-35.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Assay for cardiac troponin I does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Assay for cardiac troponin I, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay for cardiac troponin I will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1515377

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.