Assay for bilirubin

Details Assay for bilirubin Assay for bilirubin

1977-01-14

1978-01-17

Reese, Robert M.

Chemistry: physical processes

Physical processes

Crystallization

23253TP, G01N 3122, G01N 3316

Patent

active

040690164

ABSTRACT:
A method for the determination of bilirubin in liquid samples, particularly biological liquid samples. An assay method, as well as an analytical element, is disclosed. In accord with the assay method there are contacted together a liquid sample containing bilirubin as analyte and an interactive composition containing a bilirubin-active complex, the complex comprising a diffusible, bilirubin-displaceable, detectable ligand bound to a carrier which can also bind bilirubin. As a result of a competitive binding-displacement interaction between bilirubin and the complex, bilirubin binds to the carrier and displaces detectable ligand which can be selectively detected and used to determine the presence or amount of bilirubin. Appropriate carriers and detectable ligands can be chosen on the basis of their first order binding constants.

REFERENCES:
kragh-Hansen et al., Biochim. et Biophys. Acta. 365, 360-371 (1974).
Lee et al., The Journal of Pediatrics, 86, No. 2, 280-285, (1975).
Hertz, H., Scand. J. Clin. Lab. Invest. 35, 545, (1975).

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