Assay for anti-viral agent

Details Assay for anti-viral agent Assay for anti-viral agent

2006-12-12

2006-12-12

Campell, Bruce R. (Department: 1648)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S004000, C435S005000, C435S007200, C435S007900, C503S223000, C503S223000

Reexamination Certificate

active

07148022

ABSTRACT:
There is provided an assay for selecting an anti-viral agent effective against picornavirus infection. The assay selects an agent which disrupts the association between picornavirus protein 2C and the host cell protein D-AKAP2, which association has been found to be essential for successful viral replication. Also disclosed are anti-viral agents having such properties and a method of combating picornavirus replication.

REFERENCES:
patent: WO 99/29908 (1999-06-01), None
GenePept NP—937964, 2C [Foot-and-mouth disease virus Asia 1], NCBI printout.
Argos et al., Nucleic Acids Research, vol. 12 No. 8, pp. 7251-7267 (Sep. 1984).
Pfister et al., Journal of Biological Chemistry, vol. 274 No. 11, pp. 6992-7001 (Mar. 1999).
Echeverri et al., Virology, vol. 208 No. 2, pp. 540-553 (Apr. 1995).
Gazina et al., Journal of Virology, vol. 76 No. 21, pp. 11113-11122 (Nov. 2002).
Weissenhorn et al., Nature, vol. 387 No. 6631, pp. 426-430 (May 1997).

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