Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1988-04-13
1991-07-02
Warden, Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
436533, 436534, 436820, 436828, 530324, C12Q 170, G01N 33546, C07K 700
Patent
active
050285246
ABSTRACT:
Assays for an anti-pre-S antibody in a human serum by an enzyme immunoassay in which a biotin-avidin system is used are disclosed. The assays include inhibition method, sandwich method, competitive method and Protein A or anti-human IgG antibody method in a solid phase.
The assays can determine the anti-pre-S antibody titer in human sera highly sensitively and simply without use of radioactive materials.
REFERENCES:
patent: 4228237 (1980-10-01), Hevey et al.
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Neurath et al., Nature, 315: 154-156, "Hepatitis B Virus Contains Pre-S Gene Encoded Domains", May 9, 1985.
Neurath et al., Cell, 46: 429-436, "Identification and Chemical Synthesis of a Host Cell Receptor Binding Site on Hepatitis B Virus", Aug. 1, 1986.
Tijssen, Laboratory Techniques in Biochemistry and Molecular Biology, vol. 5, "Practice and Theory of Enzyme Immunoassays", Elsevier, N.Y., 1-37 (1985).
Okamoto, H. et al., 1986, Nucleotide Sequence of Cloned Hepatitis B Virus Genome, Subtype Ayr: . . . J. Gen. Virol. 67 2305.
Neurath, A. R. et al., Molecular Immun., vol. 24, No. 6: 561-568 (1987).
Neurath, A. R. et al., Advances in Virus Res., vol. 34:66-142 (1988).
Guesdon et al., Journ. of Histochem. & Cytochem. 27:8, pp. 1131-1139.
Okamoto et al., Hepatology, 6:3, pp. 354-359 (1986).
Budkowsak et al., Hepatology, 6:3, pp. 360-368 (1986).
Itoh, Y. et al., Proc. Natl. Acad. Sci: U.S.A., 83, pp. 9174-9178 (1986).
Fujisawa Yukio
Itoh Yasuaki
Nishimura Osamu
Conlin David G.
Eisenstein Ronald I.
Groelke John
Takeda Chemical Industries Ltd.
Warden Robert J.
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