Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-01-23
2007-01-23
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S007930, C435S007940, C436S518000
Reexamination Certificate
active
10376046
ABSTRACT:
A solid phase assay is used for detecting antibodies to INGAP104-118peptide, a 15-amino acid peptide that is the biologically active portion of islet neogenesis associated protein (INGAP). The isotype of the antibodies to INGAP104-118peptide can be determined. A kit can also be used in the detection of anti-INGAP104-118antibodies. Endogenous autoantibodies or antibody production during therapeutic treatment of a mammal with INGAP104-118can be monitored.
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patent: WO 98/189313 (1998-05-01), None
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Rafaeloff, R. et al., “Cloning and Sequencing of the Pancreatic Islet Neogenesis Associated Protein (INGAP) Gene and Its Expression in Islet Neogenesis in Hamsters,”J. Clin. Invest., 1997, vol. 99, No. 9, pp. 2100-2109.
Zotto, H. et al., “Possible relationship between changes in islet neogenesis and islet neogenesis-associated protein-positive cell mass induced by sucrose administration to normal hamsters”,J. of Endocrinology, 2000, vol. 165, pp. 725-733.
Taylor-Fishwick David A.
Vinik Aaron I.
Counts Gary W.
GMP Endotherapeutics, Inc.
Keller, Esq. Michael J.
Le Long V.
Lott & Friedland, P.A.
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