Assay for amoebae and probes for use therein

Details Assay for amoebae and probes for use therein Assay for amoebae and probes for use therein

1989-09-05

1991-12-10

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 27, 436501, 436 94, C12Q 168, G01N 33566, G01N 3300

Patent

active

050717421

ABSTRACT:
An assay for the determination of the presence or absence of E. histolytica and for differentiation of these from other types of amoebae, as well as for the determination of whether the E. histolytica belongs to a symptomatic or asymptomatic strain, is carried out by means of a DNA-probe adapted to selectively hybridize only to the DNA of the amoeba tested. The probes being used selectively hybridize with, and thus diagnose the presence of, symptomatic (pathogenic) and asymptomatic (non-pathogenic) strains, respectively.

REFERENCES:
Bhattacharya et al., Molecular and Biochemical Panasitology, vol. 27 (1988) 257-262 published Jan. 15, 1988.
"Abstracts of Papers", Gastroenterology, vol. 92, No. 5, Part 2, p. 1612; Samuelson et al.
"Proc. Natl. Acad. Sci. U.S.A.", (1989), vol. 86, pp. 5118-5122, (7/1989), Geomic DNA Differences between Pathogenic an Nonpathogenic Entamoeba Histoyltica; Tannich et al.
"Journal of Clinical Microbiology", vol. 27, No. 4, (1989), pp. 671-676, DNA Hybridization Probe for Clinical Diagnosis of Entameoba Histolytica; Samuelson et al.
"Infect. Immun.", vol. 57, No. 3, (1989), pp. 926-931, DNA Probes Specific for Entamoeba Histolytica Possessing Pathogenic and Nonpathogenic Zymoclemes; Garfinkel et al.
Abstract in Gastroenterology Samuelson et al. (copy not attached).

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