Assay for adrenal autoantigen

Details Assay for adrenal autoantigen Assay for adrenal autoantigen

1993-09-02

1998-01-06

Hutzell, Paula K.

Chemistry: analytical and immunological testing

For preexisting immune complex or auto-immune disease

435 71, 435 74, 435 792, 435 795, 435 18, 435195, 436811, 436503, G01N 33564, G01N 33567, G01N 33573

Patent

active

057054002

ABSTRACT:
Adrenal autoantigen is isolated and characterised as a protein obtainable from the microsome fraction of the adrenal gland, having a molecular weight of about 55,000 and antigenic towards adrenal autoantibody. The protein is used in a method for detecting adrenal autoantibodies.

REFERENCES:
patent: 3654090 (1972-04-01), Schuurs et al.
patent: 4720454 (1988-01-01), White et al.
patent: 5070192 (1991-12-01), Earnshaw et al.
patent: 5254458 (1993-10-01), Mimms
patent: 5376533 (1994-12-01), Maclaren et al.
Bednarek, J. et al. Steroid 21-Hydroxylase is a Major Autoantigen Involved in Adult Onset Auto-Immune Addison's Disease. FEBS Letters 309:51-55, 1992.
Wedlock, N. et al. Autoimmune Addison's Disease: Analysis of Autoantibody Binding Sites on Human Steroid 21-Hydroxylase. FEBS Letters 332:123-126, 1993.
Bumpus, JA et al. Bovine Adrenocortical Microsomal Hemeproteins p. 450 17.alpha. and p. 450 c-21. J. Biol. Chem. 257:12696-704, 1982.
Alberts, B et al, Molecular Biology of the Cell. New York: Garland Publishing, 1989. pp. 169-174 & 262-267.
Khoury, et al., "Surface-Reactive Antibodies to Human Adrenal Cells in Addison's Disease," Clin. exp. Immunol., 1981, 45:48-55.
Scherbaum, et al., "Development of Adrenocortical Failure in Non-Addisonian Patients with Antibodies to Adrenal Cortex," 1982, 16:345-352.
Kosowicz, et al., "A Radioimmunoassay for the Detection of Adrenal Autoantibodies," Clin. exp. Immunol., 1986, 63:671-679.
Betterle, et al., "The Natural History of Adrenal Function in Autoimmune Patients With Adrenal Autoantibodies," J. Endocr., 1988, 117:467-475.
Freeman, et al., "T and B Cell Reactivity to Adrenal Antigens in Autoimmune Addison's Disease," Clin. exp. Immunol., 1992, 88:275-279.
Bright, et al., "Adrenal Autoantibodies Bind to Adrenal Subcellular Fractions Enriched in Cytochrome-c Reductase and 5'-Nucleotidase", J. Clin. Endo. Meta., 70:95-99 (1990).
Centeno, et al., "Isolation and Characterization of a Rabbit Adrenal Autoantigen", Immunology, 24:901-910 (1973).
Chouinard, et al., "ACTH-induced Increases in Rabbit Adrenal Immunoreactive P-450.sub.17a and P-450.sub.21 ", Mol. and Cell. Endocrinology, 68:29-34 (1990).
Furmaniak et al., "Immunoprecipitation of Human Adrenal Microsomal Antigen," FEB, 231:25-28 (1988).
King et al., "Control of Yeast Mating Signal Transduction by a Mammalian .beta..sub.2 -Adrenergic Receptor and G-.sub.S .alpha. Subunit", Science, 250:121-125 (1990).
Krohn et al., "Identification by Molecular Cloning of an Autoantigen Associated with Addison's Disease as Steroid 17.alpha.-Hydroxylase," The Lancet, 339:770-773 (1992).
White et al., "Cloning and Expression of cDNA Encoding a Bovine Adrenal Cytochrome P-450 Specific for Steroid 21-Hydroxylation," Proc. Natl. Acad. Sci., 81:1986-1990 (1984).
White et al., "Structure of Human Steroid 21-Hydroxylase Genes", Proc. Natl. Acad. Sci., 83:5111-5115 (1986).
Wingvist et al., "21-Hydroxylase, A Major Autoantigen in Idiopathic Addison's Disesase," The Lancet, 339:1559-1562 (1992).
Editorials, The Lancet, 339:779-780 (1992).
Gosling, "A Decade of Development in Immunoassay Methodology", Clin. Chem., 36(8):1408-1427 (1990).

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