Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1995-05-10
1996-10-15
Warden, Robert
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
436501, 436810, 422311, 422101, 210695, 210222, G01N 33553
Patent
active
055653650
ABSTRACT:
A system for assaying a fluid sample by detection of radiation emitted from a ligand/conjugate complex formed on a plurality of beads dimensioned within a specified range of diameters, the beads being disposed as a porous mass in a conduit adjacent a fluid-porous screen having pores of lesser diameter than the range of diameters of the beads. A plurality of paramagnetic particles is suspended across the conduit by a magnetic field of sufficient intensity to array the paramagnetic particles as the fluid-porous screen.
REFERENCES:
patent: 1716321 (1927-05-01), Pearson
patent: 2798718 (1951-10-01), Gross
patent: 3002092 (1961-09-01), Cary
patent: 3025142 (1962-03-01), Williams
patent: 3492396 (1970-01-01), Dalton et al.
patent: 3600063 (1971-08-01), Bowen
patent: 3740552 (1973-06-01), Pressman
patent: 4059685 (1977-11-01), Johnson
patent: 4153675 (1979-05-01), Kleinerman
patent: 4173392 (1979-11-01), Ekinaka et al.
patent: 4201831 (1980-05-01), Slusarczuk et al.
patent: 4268171 (1981-05-01), Sternberg
patent: 4314905 (1982-02-01), Etzel et al.
patent: 4348107 (1982-09-01), Leif
patent: 4425438 (1984-01-01), Bauman et al.
patent: 4454234 (1984-06-01), Czerlinski
patent: 4469787 (1984-09-01), Woods et al.
patent: 4495074 (1985-01-01), Hagiuara et al.
patent: 4505260 (1985-03-01), Metzger
patent: 4582809 (1986-04-01), Block et al.
patent: 4585623 (1986-04-01), Chandler
patent: 4652533 (1987-03-01), Jolley
patent: 4668591 (1987-05-01), Minemura
patent: 4678268 (1987-07-01), Russo et al.
patent: 4713347 (1987-12-01), Mitchell et al.
patent: 4714345 (1987-12-01), Schrader
patent: 4738773 (1988-04-01), Muller-Ruchholtz et al.
patent: 4775515 (1988-10-01), Cottingham
patent: 4780423 (1988-10-01), Bluestein et al.
patent: 4895650 (1990-01-01), Wang
patent: 4912051 (1990-03-01), Zaromb
patent: 4963498 (1990-10-01), Hillman et al.
patent: 5110624 (1992-05-01), Noble et al.
patent: 5110727 (1992-05-01), Oberhardt
patent: 5120643 (1992-06-01), Ching et al.
patent: 5183486 (1993-02-01), Gatten et al.
patent: 5183740 (1993-02-01), Ligler et al.
patent: 5372783 (1994-12-01), Lackie
Friguet et al., "Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay", Jour. of Immun. Methods, 77, pp. 305-319, 1985.
Plant et al., "Liposome-Enhanced Flow Injection Immunoanalysis"., Biotechnology, vol. 6., Mar. 1988., pp. 266-269.
Sato et al., "A Novel Method for Isolating Specific Endocytic Vesicles Using Very Fine Ferrite Particles Coated With Biological Ligands and the High-Gradient Magnetic Separation Technique"., J. Biochem., vol. 100; No. 6., 1986; 1481-1492.
Gunaratna et al., "Noncompetitive flow injection immunoassay for a hapten, .alpha.-(Difluoromethyl)ornithine", Anal. Chem, 1993, 65, pp. 1152-1157.
G. Gubitz et al., "Flow-injection immunassays", Analytica Chimica Acta, 283, 1993, pp. 421-428.
Pollema et al., "Flow injection renewable surface immunoassay: a new approach to immunoanalysis with fluorescence detection", Anal. Chem., 1994, pp. 1825-1831.
Sambucetti et al., "Process For Purification of Magnetic Ink", IBM Technical Disclosure Bulletin, vol. 18, No. 2, Jul. 1975.
Freytag et al., "Affinity-Column-Mediated Immunoenzymometric Assays: Influence of Affinity-Column Ligand and Valency of Antibody-Enzyme Conjugates", Clin. Chem., V. 30, No. 9, 1494-1498, 1984.
Freytag et al., "A Highly Sensitive Affinity-Column-Mediated Immunometric Assay, as Exemplified by Digoxin", Clin. Chem., V. 30, No. 3, 417-420, 1984.
O'Shannessy et al., "Determination of Rate of Equilibrium Binding Constants for Macromolecular Interactions Using Surface Plasmon Resonance: Use of Nonlinear Least Squares Analysis Methods", Anal. Biochem, V. 212, 457-468, 1993.
Ralf W. Glaser, "Antigen-Antibody Binding and Mass Transport by Convection and Diffusion to a Surface: A Two-Dimensional Computer Model of Binding and Dissociation Kinetics", Anal. Biochem., V. 213, 152-161, 1993.
Warren J. Smith, "Modern Optical Engineering. The Design of Optical Systems", McGraw-Hill, Inc. (pubs) .COPYRGT.1966.
Hudson, "Infrared Systems Engineering", Wiley-Interscience, 1969.
Pollema et al., "Sequential Injection Immunoassay Utilizing Immunomagnetic Beads", Anal. Chem., vol. 64, 1356-1361, 1992.
Forrest, "Development and Application Of A Fully Automated Continous Flow Radioimmunoassay System", Ann. Clin. Biochem., V. 14, 1-11, 1977.
M. E. Jolley et al., "Particle Concentration Fluorescence Immunoassay (PCFIA); A New Rapid Immunoassay Technique with High Sensitivity", Journal of Immunological Methods, vol. 67, 21-35, 1984.
Sapidyne, Inc.
Snider Theresa T.
Warden Robert
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