Assay and purification of amyloid components, applications, and

Details Assay and purification of amyloid components, applications, and Assay and purification of amyloid components, applications, and

1986-06-16

1988-11-01

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435805, 435810, 436501, 436528, 436529, 436530, 436531, 436532, 436533, 436534, 436518, 436808, 436809, 436810, 436815, 530386, 530395, 530411, 530412, 530415, 530812, 530813, 530814, G01N 3353, G01N 33577

Patent

active

047820144

ABSTRACT:
The invention relates to a new method of immunological analysis for serum amyloid A protein (SAA) and serum amyloid P-component (SAP), kits therefor and a method of purification of SAA and SAP. These methods are based on the efficient binding of SAP to a plastic surface and to carriers bearing nitrated phenyl groups in the presence of calcium and related bivalent ions, and of SAA to a plastic surface and to carriers bearing nitrated phenyl groups with or without calcium ions. The method of immunological analysis allows for rapid and reliable screening of serum samples with a high sensitivity. SAA and SAP play a key role in the diagnosis and management of inflammatory diseases.

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