Assay

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

Reexamination Certificate

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Details

C435S004000, C435S007100, C435S007930, C435S007940, C435S007950, C436S501000, C436S506000, C436S512000, C436S513000, C436S541000

Reexamination Certificate

active

07452731

ABSTRACT:
A method for determining the risk of an individual of suffering from inflammation, opportunistic infection or disruption of immunoglobulin metabolism, comprising (a) determining the level of fragmentation or modification of Fc function of immunoglobulins in a sample taken from the individual and (b) determining thereby the risk of inflammation, impaired immune response or opportunistic infection. The invention also provides the use of a trypsin inhibitor in the manufacture of a medicament for use in the treatment or prevention of a disorder associated with elevated trypsin activity which is correlated with IgG fragmentation or modification.

REFERENCES:
patent: 5807752 (1998-09-01), Brizgys et al.
patent: WO 99/32659 (1999-07-01), None
patent: WO 00/44733 (2000-08-01), None
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Patel, Y., SAMJ Forum. vol. 89, No. 7. pp. 742-743. 1999.
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Petyaev et al., “Subsequent Use of Protein A and Protein L for the Study of the Content, Distribution and Composition of Anti-Lipoprotein Immune Complexes in Patients with Atherosclerosis,” J. Submicroscop, Cytol, & Pathol., vol. 32, No. 3, Jul. 2000, p. 477.

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