Assay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Details

C435S002000, C435S004000, C435S007100, C435S007400, C435S007500, C435S007600, C435S007910, C435S007920, C435S007930, C435S007940, C436S043000, C436S066000, C436S086000, C436S164000, C436S174000, C436S501000, C436S512000, C436S519000, C436S532000, C436S536000, C436S538000, C436S540000

Reexamination Certificate

active

10897433

ABSTRACT:
The present invention relates to assay methods for the determination of cobalamin or vitamin B12in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin, comprising contacting a cell free sample of a body fluid with an immobilised or immobilizable specific binding ligand for TC II or holo TC II, separating a ligand bound fraction from a non-ligand bound fraction and measuring the holo-TC II or TC-II bound cobalamin content therein.

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Kuemmerle et al. 1992. Clin. Chem. vol. 38(10): 2073-2077.
McLean et al. 1997. Blood. vol. 89(1): 235-242.
Quadros et al. 1996. Biochem and Biophy. Res. vol. 222: 149-154.
Nexoe, Ebba, “Characterization of the cobalamins attached to transcobalamin I and transcobalamin II in human plasma”, 1977, XP002127542.
Rothenberg S.P., Quadros E.V., “Transcobalamin II and the membrane receptor of the transcobalamin II-cobalamin complex”, 1995, XP002127541.
Kuemmerle et al. 1992. Automated Assay of Vitamin B12 by the Abbott IMx (TM) Analyzer. Clin Chem. 38(10):2073-2077.
McLean et al. 1997. Antibodies to Transcobalamin II Block In Vitro Proliferation of Leukemic Cells. Blood. 89(1):235-242.
Quadros et al. 1996. Characterization of Monoclonal Antibodies to Epitopes of Human Transcobalamin II. Biochem. Biophy. Res. Comm. 222:149-154.
Wickramasinghe et al. 1993. Correlations between holo-transcobalamin II, holo-haptocorrin, and total B12 in serum samples from healthy subjects and patients. J. Clin. Path. 46:537-539.
Nexoe, Ebba, “Characterization of the cobalamins attached to transcobalamin I and transcobalamin II in human plasma”, 1977, XP002127542, Abstract Only.
Rothenberg S.P., Quadros E.V., “Transcobalamin II and the membrane receptor of the transcobalamin II-cobalamin complex”, 1995, XP002127541, Abstract Only.

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