Aspergillus terreus blasticidin S deaminase, a blasticidin S dea

Details Aspergillus terreus blasticidin S deaminase, a blasticidin S dea Aspergillus terreus blasticidin S deaminase, a blasticidin S dea

1993-04-27

1996-06-18

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4353201, 536 232, C12N 514, C12N 1555, C12N 1563

Patent

active

055277012

ABSTRACT:
According to the present invention, it is provided blasticidin S (hereinafter referred to as BcS) deaminase, a gene coding for the BcS deaminase, a vector incorporating the BcS deaminase gene and a transformant or a transductant transformed or transduced with the vector.
It is an object of the present invention to provide BcS deaminase, a BcS deaminase gene, a vector incorporating the BcS deaminase gene and a transformant containing the vector by focusing on the fact that blasticidin S is an aminonucleoside antibiotic capable of inhibiting a protein synthesis in the wide range of organisms and is generally used as an agricultural antibiotic.
It is another object of the present invention to establish expression vectors of above-mentioned BcS gene and to produce useful plants having drug resistance against specific agricultural chemicals.

REFERENCES:
Yamaguchi et al., J. Antibiotics 28:7-14 (1975).
Yamaguchi et al., Agric. Biol. Chem. 49:3355-3361 (1985).
Kimura et al., Mol. Gen. Genet. 242:121-129 (1994).
Kobayashi et al., Agric. Biol. Chem. 55:3155-3157 (1991).
Kamakura et al., Agric. Biol. Chem. 51:3165-3168 (1987).
Yanai et al., Curr. Genet. 19:221-226 (1991).
Sutoh, Plasmid 30:150-154 (1993).

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