Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1992-10-05
1994-06-07
Wityshyn, Michael G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 29, 435119, 435911, 435913, 435917, 514291, 540456, C12Q 118, C12N 100, C07D49800
Patent
active
053188950
ABSTRACT:
Disclosed are new Aspergillus niger mutants which can be used for identifying active FK-506/ rapamycin type, or cyclosporin A type inununosuppressants in a broth, natural product extract, or composition exhibiting inununosuppressant activity. Specifically disclosed are the new mutants, ATCC No. 74085 (MF 5659), which is sensitive to FK-506 and rapamycin but resistant to cyclosporin A; ATCC No. 74086 (MF 5659) which is resistant to FK-506, cyclosporin A and rapamycin; and ATCC No. 74087 (MF 5661) which is resistant to FK-506 and rapamycin, but sensitive to cyclosporin A.
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Byrne Kevin M.
Kahn Jennifer N.
Kaplan Louis
Monaghan Richard J.
Caruso Charles M.
Merck & Co. , Inc.
Mohamed Abdel A.
Thies J. Eric
Wityshyn Michael G.
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