Aspergillus genus showing resistance to cerulenin and L-methioni

Details Aspergillus genus showing resistance to cerulenin and L-methioni Aspergillus genus showing resistance to cerulenin and L-methioni

1997-10-30

1999-07-20

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435125, 4352543, 4352561, 435913, C12P 762, C12N 114, C12N 116

Patent

active

059255510

ABSTRACT:
The present invention relates to a novel mutant of Aspergillus terreus which shows a resistance to both cerulenin and L-methionine analogue, and a process for preparing mevinolinic acid which comprises aerobic culture of the mutant strain and recovery of mevinolinic acid. The mutant of the present invention provides a remarkably high productivity of mevinolinic acid while reducing the production of byproducts such as mevinolinic acid analogues, when compared with a wild type Aspergillus terreus isolated from soil environment in Korea, and it successfully produce mevinolinic acid by employing monosaccharides such as glucose and galactose, unlike the mother strain.

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