Aspartyl protease inhibitors

Details Aspartyl protease inhibitors Aspartyl protease inhibitors

2006-11-07

2006-11-07

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C514S616000

Reexamination Certificate

active

07132568

ABSTRACT:
The present invention provides compounds having formula (I):wherein R′, R0, R1, X1, R2, R3, R3′, X2, X3and R4are as defined herein, and pharmaceutical compositions thereof. The present invention also provides methods of inhibiting proteases, more specifically aspartyl proteases. In certain embodiments, compounds inhibit BACE (β-site APP-cleaving enzyme), and thus are useful in the treatment or prevention of a disease characterized by β-amyloid deposits in the brain (including, but not limited to, Alzheimer's Disease). The present invention also provides methods for preparing compounds of the invention.

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