Aspartyl protease inhibitors

Details Aspartyl protease inhibitors Aspartyl protease inhibitors

1996-01-26

1999-03-16

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

514193, 514255, 514361, 514372, 514397, 514398, 514424, 544231, 544336, 544384, 548127, 548206, 5483111, 5483235, 5483241, 548550, C07D30720, C07D31906, C07D49304, C07D21160, C07D24104, C07D27706

Patent

active

058832521

ABSTRACT:
This invention relates to a novel class of compounds that are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting aspartyl protease activity and methods for treating viral infections using the compounds and compositions of this invention.

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