Aspartic protease inhibitors

Details Aspartic protease inhibitors Aspartic protease inhibitors

2006-11-07

2006-11-07

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S106000, C544S111000, C544S224000, C544S242000, C546S268100, C546S282100, C514S231200, C514S256000, C514S336000, C514S340000

Reexamination Certificate

active

07132420

ABSTRACT:
The present invention provides an aspartic proteinase-inhibiting compound of the formula:wherein a, b, c, d, and e, can be the same or different and each are R7, OR7, SR7, NR7R8, NHCOR7, CO2R7, CN, NO2, NH2, N3, or a halogen, wherein R7and R8are independently H or an alkyl. Substituents R1or R2are each H or an alkyl. Substituent R3is a straight chain or branched alkyl, alkenyl, or alkynyl substituent, or is a cycloalkyl. Substituent A is OH, NH2, or SH.Further provided are pharmaceutical compositions, which include a therapeutically effective amount of at least one of the foregoing compounds, and therapeutic methods of using the foregoing compounds.

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