Aspartame synthesis

Details Aspartame synthesis Aspartame synthesis

1984-05-25

1987-04-07

Moyer, Donald B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C10102

Patent

active

046563040

ABSTRACT:
A process for the preparation of the N-L-.alpha.-aspartyl-L-phenylalanine 1-methyl ester (aspartame) which is characterized by adding phosphoric acid and a lower alkyl alcohol to the reaction mixture containing N-formyl .alpha.-L-aspartyl- and .beta.-L-aspartyl-L-phenyl-alanine methyl ester and only one of the resultant deformylated isomers, i.e. aspartame phosphate precipitates.
The .alpha.-isomer phosphate is collected by filtration and converted to free aspartame by treatment with a base.

REFERENCES:
patent: 3492131 (1970-01-01), Schlatter et al.
patent: 3833553 (1974-09-01), Ariyashi et al.
patent: 3962207 (1976-06-01), Uchiyama et al.
patent: 4071511 (1978-01-01), Takemoto et al.
patent: 4173562 (1979-11-01), Bachman et al.
Handbook of Chemistry and Physics, 57th ed., CRC Press, Ohio, 1976-1977, p. B-139.

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