Asparaginases

Details Asparaginases Asparaginases

2009-11-06

2010-11-09

Nashed, Nashaat T (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S252300, C435S254110, C435S254300, C435S320100, C426S049000, C536S023200, C536S023100

Reexamination Certificate

active

07829320

ABSTRACT:
The invention relates to new asparaginases having improved properties, preferably improved thermotolerance, such as improved activity at high temperatures and/or improved thermostability. The invention also relates to DNA sequences encoding such improved asparaginases, their production in a recombinant host cell, as well as methods of using the asparaginases, in particular for reduction of acrylamide in foods. The invention furthermore relates to methods of generating and preparing asparaginase variants having improved properties.

REFERENCES:
patent: 1 704 782 (2006-09-01), None
patent: WO2004/026042 (2004-04-01), None
patent: WO2004/030468 (2004-04-01), None
patent: WO2004/032648 (2004-04-01), None
Lubkowski et al, “Atomic resolution structure ofErwinia chrysanthemiL-asparaginase”, Acta Cryst. D, vol. 59, pp. 84-92 (2003).
Watanabe K. et al, “Designing Thermostable Proteins: Ancestral Mutants of 3-Isopropylmalate Dehydrogenase Designed by suing a Phylogenetic Tree”, Journal of Molecular Biology, vol. 335, pp. 664-674 (2006.
Kotzia et al, Journal of Biotechnology, vol. 119, pp. 309-323 (2005).
Liu et al, Protein Engineering, vol. 16, No. 1, pp. 19-25 (2003).

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