Asp-Pro-Arg .alpha.-keto-amide enzyme inhibitors

Details Asp-Pro-Arg .alpha.-keto-amide enzyme inhibitors Asp-Pro-Arg .alpha.-keto-amide enzyme inhibitors

1992-10-16

1994-12-06

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514822, 530331, A61K 3700, A61K 3702, C07K 508

Patent

active

053710720

ABSTRACT:
Asp-Pro-Arg alpha-keto-amide derivatives, and their pharmaceutically acceptable salts and compositions, for use as antithrombotic agents in mammals are disclosed. The method of use of these inhibitor compounds for treatment or prevention of conditions of abnormal thrombus formation in mammals is also disclosed. Further disclosed are alpha-hydroxy amide compounds used as intermediates in the preparation of the keto-amide compounds.

REFERENCES:
patent: 3966701 (1976-06-01), Dorman et al.
patent: 4161522 (1979-07-01), Hamburger
patent: 4171299 (1979-10-01), Hamburger
patent: 4478745 (1984-10-01), Bojusz et al.
patent: 5221752 (1993-06-01), Someno et al.

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