[Asn.sup.2 ]-thymosin .alpha..sub.1 and analogs thereof

Details [Asn.sup.2 ]-thymosin .alpha..sub.1 and analogs thereof [Asn.sup.2 ]-thymosin .alpha..sub.1 and analogs thereof

1978-01-23

1978-09-26

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

041169514

ABSTRACT:
Thymosin .alpha..sub.1, was chemically synthesized by the fragment condensation of the protected amino terminal tetradecapeptide with the protected carboxyl terminal tetradecapeptide. Similarly prepared was the analog [Asn.sup.2 ]-thymosin .alpha..sub.1 utilizing the appropriately modified protected amino terminal tetradecapeptide. Both products are active as agents which affect regulation, differentiation and function of thymus dependent lymphocytes (T cells).

REFERENCES:
patent: 4077949 (1978-03-01), Goldstein
patent: 4079127 (1978-03-01), Goldstein et al.

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