Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1994-01-14
1996-05-28
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
435171, 536 111, 536 41, 536 5, 552526, 552540, C12P 102, A61K 3156, C07J 900
Patent
active
055211690
ABSTRACT:
Ascosteroside, obtainable by cultivation of a strain of Ascotricha amphitricha A.T.C.C. No. 74237, analogs thereof and salts and prodrugs of these compounds. The compounds have antifungal activity for use in a method for treating and preventing a fungal infection. Further, the compounds are useful in a method for inhibiting fungal growth.
REFERENCES:
Wehrli, et al., "Structure of the novel steroidal antibiotic squalamine determined by two-dimensional NMR spectroscopy." Steroids 58:370-378 (1993).
S. Inouye et al., J. Syn. Org. Chem. Japan, "Current Antifungal Antibiotics", vol. 51, No. 4, pp. 327-349, 1993.
The Merck Index, 9th Ed., 6735. Ouabain, p. 896 (1976).
CA Selects: Fungicides, B. Schlegel, et al., "A novel antifungal antibiotic manufactured by cultures of Tolypocladium or Sesquicillopsis", Issue 3, 1993, 118:37554q (abstract of DE 4115490).
L. Minale et al., Progress in the Chemistry of Organic Natural Products, Edited by Herz et al., Springer-Verlag, Wien, N.Y., 1993, "Steroidal Oligoglycosides and Polyhydroxysteriods from Echinoderms", pp. 75-77 and pp. 285-297.
Gorman Jessica A.
Leet John E.
Mamber Stephen W.
O'Sullivan Joseph
Babajko Suzanne E.
Bristol--Myers Squibb Company
Rollins John W.
Ware Deborah K.
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