Ascorbyl-phosphoryl-cholesterol

Details Ascorbyl-phosphoryl-cholesterol Ascorbyl-phosphoryl-cholesterol

1997-04-11

1999-02-02

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

514169, 514474, 514844, 514944, A61K 700, A61K 31375

Patent

active

058661476

ABSTRACT:
This disclosure relates to a novel derivative of L-ascorbic acid which is stable, easily incorporated into cosmetically acceptable vehicles and enzymatically bioreversible in the skin to free ascorbic acid and a safe cholesterol component. An exemplary embodiment is 3'-(L-ascorbyl-2-phosphoryl)-cholesterol which is shown in Formula I. ##STR1##

REFERENCES:
patent: 3151127 (1964-09-01), Spanel
patent: 4564686 (1986-01-01), Ogata
patent: 4939128 (1990-07-01), Kato et al.
patent: 4954532 (1990-09-01), Elliott et al.
patent: 5306713 (1994-04-01), Suetsugu et al.
patent: 5336485 (1994-08-01), Fariss
patent: 5474991 (1995-12-01), Ogata
Menon et al., Structural Basis for the Barrier Abnormality Following Inhibition of HMG CoA Reductase in Murine Epidermis, J. Invest. Dermatol., vol. 98, pp. 209-219 (1992).
Steinhart et al., Pro-and Antioxidative Effect of Ascorbic Acid on L-Tryptophan in the System FE.sup.3+ /Ascorbic Acid/O.sub.2, J. Agric. Food Chem., vol. 41, pp. 2275-2277 (1993).
Sakamoto et al., Measurement Method of Efficacy of Antidandruff Cosmetics and Development of the New Active Commercial Product, IFSCC, Yokohama, vol. B206, pp. 823-864 (1993.

Affiliated with

Also associated with

Rating

Ascorbyl-phosphoryl-cholesterol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ascorbyl-phosphoryl-cholesterol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ascorbyl-phosphoryl-cholesterol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1114737