Ascorbyl-phosphoryl-cholesterol

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

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Details

514169, 514474, 514844, 514944, A61K 700, A61K 31375

Patent

active

058661476

ABSTRACT:
This disclosure relates to a novel derivative of L-ascorbic acid which is stable, easily incorporated into cosmetically acceptable vehicles and enzymatically bioreversible in the skin to free ascorbic acid and a safe cholesterol component. An exemplary embodiment is 3'-(L-ascorbyl-2-phosphoryl)-cholesterol which is shown in Formula I. ##STR1##

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patent: 5474991 (1995-12-01), Ogata
Menon et al., Structural Basis for the Barrier Abnormality Following Inhibition of HMG CoA Reductase in Murine Epidermis, J. Invest. Dermatol., vol. 98, pp. 209-219 (1992).
Steinhart et al., Pro-and Antioxidative Effect of Ascorbic Acid on L-Tryptophan in the System FE.sup.3+ /Ascorbic Acid/O.sub.2, J. Agric. Food Chem., vol. 41, pp. 2275-2277 (1993).
Sakamoto et al., Measurement Method of Efficacy of Antidandruff Cosmetics and Development of the New Active Commercial Product, IFSCC, Yokohama, vol. B206, pp. 823-864 (1993.

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