Ascorbic acid ester

Details Ascorbic acid ester Ascorbic acid ester

1988-06-10

1989-07-04

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30762

Patent

active

048452467

ABSTRACT:
6-O-(2-keto-L-gulonoyl)-L-ascorbate substantially free from 2-keto-L-gulonic acid is produced by allowing an acid to act on 2-keto-L-gulonic acid in an inert organic solvent and recovering 6-O-(2-keto-L-gulonoyl)-L-ascorbate from the reaction mixture.
6-O-(2-keto-L-gulonoyl)-L-ascorbate is more fat-soluble than L-ascorbic acid and is expected of the use as a prodrug for L-ascorbic acid that can be absorbed from the intestinal tract.

REFERENCES:
patent: 2185383 (1940-01-01), Pasternack et al.
Ahmedabad, Chemical Abstracts, vol. 97, No. 9, Aug. 30, 1982, p. 671, No. 72714m.
Khacaturov et al., Chemical Abstracts, vol. 94, No. 8 (Feb. 23, 1981) p. 364 No. 52833j.
Koen et al., Chemical Abstracts, vol. 96, No. 22, Jun. 8, 1987, p. 428, No. 187386C.
Basnak et al., Chemical Abstracts, vol. 106, No. 23, Jun. 8, 1987, p. 777, No. 196736U.

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