Ascomycin crystalline forms and preparation thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C540S456000

Reexamination Certificate

active

07439252

ABSTRACT:
The present invention provides novel crystalline forms of ascomycin as well as processes for the preparation thereof and pharmaceutical compositions comprising such crystalline forms of ascomycin.

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Z. Song et al. “Highly Chemoselective Trichloracetimidate-Mediated Alkylation of Ascomycin: A Convergent, Practical Synthesis of the Immunosupporessant L-733,725” J. Org. Chem. 1999, v. 64, p. 1859-1867.

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