Ascochlorin derivatives, and pharmaceutical composition containi

Details Ascochlorin derivatives, and pharmaceutical composition containi Ascochlorin derivatives, and pharmaceutical composition containi

1982-08-27

1985-02-19

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560 53, 562463, 562464, 546318, 546326, 514571, C07C 5992, C07C 69738, A61K 3119, A61K 31215

Patent

active

045005443

ABSTRACT:
Ascochlorin derivatives of the formula: ##STR1## wherein R is a hydroxyl group, a lower alkoxy group, a pyridyl group, an amino group, a dialkylamino group, a phenoxyalkyl group which may have a substituent in the nucleus, or a phenyl group which may have a substituent in the nucleus; and n is an integer of 0 to 5, a process for preparing the same and a pharmaceutical composition containing the same are disclosed.
The derivatives are useful to treat diabetes, improve lipid metabolism and control tumors.

REFERENCES:
patent: 3546073 (1970-12-01), Evans et al.
patent: 3995061 (1976-11-01), Hosokawa et al.
Chem. Abstracts, vol. 94, No. 13, Abst. No. 96, 316x, Mar. 30, 1981.
Chem. Abstracts, vol. 86, No. 6, Abst. No. 34, 279p, Feb. 7, 1977.
Sherif, E. A. et al., "Synthesis of Chalcones, Flavanones Isolated from Popowia Cauliflora and Their Analogues", Agric. Biol. Chem., vol. 45, (2), 531-533, (1981).

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