As a probe of serotonin uptake harmaline

Details As a probe of serotonin uptake harmaline As a probe of serotonin uptake harmaline

1990-03-16

1993-10-26

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 4, 436172, 436503, C12Q 100, C12N 1300, G01N 2176

Patent

active

052565335

ABSTRACT:
Beta carbolines are naturally occurring fluorescent analogues of several classes of neurotransmitters, namely indoles, indoleamines and catecholamines. The fluorescent properties of the beta carboline, harmaline, has been used to assess serotonin uptake systems by direct visualization. This method may provide a tool to examine the mode of action of new or existing serotonergic active compounds or the efficacy of a serotonergic active compound for individual patients in need thereof.

REFERENCES:
Bartonicek (1971) Pharmacology, 5(1), 36-42 in Chem Abst 74, p. 205, Abst #11808y.
Gineln et al, (1983) Res. Commun. Chem, Pathol. Pharmacol. 41(2), 349-352, in Chem Abstr., 99(17), p. 429, Abst. #137789.
Goldstein et al, (1971) Proc. Nat. Acad Sci., USA, 68(8), 1742-1747, Snyder (1984) Science, 224, 22-31.
McGeer et al, (1987) "Molecular Neurobiology of the Mammalian Brain", pp. 319-347.
Airaksinen et al (1978a) Arzneimittelforsch., 28(1), Heft 1:42-46.
Airaksinen et al (1978b) Acta pharmacol. et toxicol., 43:375-80.
Airaksinen et al (1987) Pharmacol. and Toxicol., 605-8.
Airaksinen et al (1981) Med. Biol., 59:21-34.
Airaksinen et al (1981b) Med. Biol., 59:190-211.
Airaksinen et al (1984) Acta pharmacol. et toxicol., 55:380-85.
Blackwell, B. (1981) Drugs, 21:201.
Bosin et al (1985) J. Chromatogr., 341:287-93.
Briley et al (1979) Eur. J. Pharmacol., 58:347-48.
Briley et al (1980) Science, 209(11):303-305.
Bruning et al (1985) Eur. Biochem., 153:95-99.
Bukard et al (1977) Biochem. Pharmacol., 26:1303-6.
Canessa et al (1973) J. membrane Biol., 13:263-82.
Erecinska, M. (1987) Bio. Phrama., 36(1):3547-55.
Fuentes et al (1971) Neuropharmacology, 10:15-23.
Fuller, R. W. (1976) Life Sci., 19:625.
de la Torre et al (1976) Histochem, J., 49:81.
Fuller et al (1986) Life Sci., 38:409.
Gershon et al (1962) Archs. Int. Pharmacodyn. Ther., 135:31-56.
Glennon et al (1979) J. Med. Chem., 22:428.
Glennon, R. A. (1981) Life Sci., 29:861.
Hsu et al (1975) Res. Commun. Chem. Pathol. Pharmacol., 12:355.
Inoue et al (1983) Anal. Biochem., 132:468.
Langer et al. (1984) Eur. J. Pharmacol., 98:153.
Leonard, B. E. (1988) J. Clin. Psychiatry, 49:8.
Mandel et al (1974) Science 186:741.
Marcusson et al (1986) Molec. Pharmacol., 30:121.
Muller et al (1981) Pharm. Biochem. & Behavior, 14:694-99.
Redburn et al (1987) J. Neurosci., 7:319.
Paul et al (1981) Arch. Gen. Psychiatry, 38:1315-17.
Paul et al (1981) Life Sciences, 28:2753-60.
Paul et al (1980) Life Sciences, 26:953-59.
Rommelspacher et al (1978) J. Neurochem., 30:1573-78.
Rommelspacher et al (1984) Arch. Pharmac., 327:107-13.
Rommelspacher et al (1980) FEBS Letters, 109(2):209-12.
Rommelspacher et al (1985) J. Pharmac., 109:363-71.
Schoenenweid et al (1986) J. Physiol., 81:19-25.
Sepulveda et al (1973) Biochemica et Biophysica Acta, 373:527-31.
Sklar et al (1984) J. Bio. Chem., 259(9):5661-9.
Sneddon (1973) Prog. Neurobiol., 1:153-98.
Sheddon (1969) Br. J. Pharmac., 37:680-88.
Sneddon (1971) Br. J. Pharmac., 43:834-44.
Stahl (1985) Pharmacol. Bulletin, 21(3):663-71.
Susilo et al (1987) Arch. Pharmac., 335:70-6.
Thomas et al (1979) Exp. Eye Res., 28:55-61.
Titus et al (1981) Proc. Natl. Acad. Sci., 78:519-23.
Stanley et al (1981) Science, 216(18):1337-39.
Wyatt et al (1975) Science, 187:853-55.
Wirz-Justice (1988) Experientia, 44:145-52.
Gershon et al (1962) Arch. Int. Pharmacodyn., CXXXV(1-2):31-56.
McKenna et al (1984) Journal of Ethnopharmacology, 10:195-223.
Schultes et al eds, The Botany and Chemistry of Hallucinogens (1973): pp. 106-111.
Schultes et al eds. Plants of the Gods,

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