Arylthioalkylphenyl carboxylic acids, derivatives thereof, compo

Details Arylthioalkylphenyl carboxylic acids, derivatives thereof, compo Arylthioalkylphenyl carboxylic acids, derivatives thereof, compo

1988-10-31

1991-04-09

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514533, 514539, 514543, 514562, 514569, 514571, 514602, 514604, 514605, 548252, 548253, 560 10, 560 11, 560 12, 562427, 562429, 562430, 564 81, 564 91, 564 99, C07C32100, A61K 3141

Patent

active

050065424

ABSTRACT:
Arylthioalkylphenylcarboxylic acids are provided which have the structure ##STR1## wherein Ar represents an aryl group including phenyl or naphthyl which may or may not include one or more substituents, X is COOR where R is hydrogen, alkali metal, or lower alkyl, or X is 5-tetrazolyl or ##STR2## where R.sup.1 is lower alkyl or aryl, p is 1 to 5, and m is 1 to 4. These compounds are cardiovascular agents which exhibit thromboxane antagonist activity and thus are useful in the treatment of thrombotic and vasopastic diseases.

REFERENCES:
patent: 4258058 (1981-03-01), Witte
patent: 4443477 (1984-04-01), Witte
patent: 4552616 (1988-06-01), Hall
patent: 4752613 (1988-06-01), Floyd
patent: 4755524 (1988-07-01), Mueller

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