Arylthioalkylphenyl carboxylic acids, compositions containing sa

Details Arylthioalkylphenyl carboxylic acids, compositions containing sa Arylthioalkylphenyl carboxylic acids, compositions containing sa

1987-06-29

1988-06-21

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514533, 514539, 514544, 514562, 514569, 514570, 560 9, 560 10, 560 11, 560 12, 560 18, 562426, 562427, 562429, 562430, 562432, C07C14940, A61K 31215

Patent

active

047526165

ABSTRACT:
Arylthioalkylphenylcarboxylic acids are provided which have the structure ##STR1## wherein Ar represents an aryl group including phenyl or naphthyl which may or may not include one or more substituents, A is ##STR2## R is hydrogen, alkali metal or lower alkyl, m is 0, 1, 2, or 3, n is 0, 1, or 2, p is 1 to 5, q, is 0, 1, 2, or 3, r is 0, 1, 2, or 3. These compounds are cardiovascular agents which exhibit thromboxane antagonist activity and thus are useful in the treatment of thrombotic disease.

REFERENCES:
patent: 3385886 (1968-05-01), Nicholson
patent: 3600437 (1971-08-01), Marshall
patent: 3824274 (1974-07-01), Franke
patent: 3825587 (1974-07-01), Diamond
patent: 3845089 (1974-10-01), Henrick
patent: 3880916 (1975-04-01), Dickel
patent: 4074057 (1978-02-01), Kaukematsu
patent: 4258058 (1981-03-01), Witte et al.
patent: 4443477 (1984-04-01), Witte et al.

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