Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-03-21
1997-10-28
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
5462764, 5462804, C07D21316
Patent
active
056819617
ABSTRACT:
The invention relates to new arylsulphonamides of the formula ##STR1## (wherein A, B and R.sub.1 to R.sub.6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R.sub.4 and R.sub.5 together represent a carbon-carbon bond, and the addition salts thereof, more particularly for pharmaceutical use the physiologically acceptable addition salts thereof with inorganic or organic bases, if R.sub.6 represents a hydroxy group) which have useful pharmacological properties, particularly antithrombotic activities and thromboxane-mediating activities. Furthermore, the new compounds are also thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH). They also have an effect on PGE.sub.2 production.
REFERENCES:
patent: 4317828 (1982-03-01), Tanouchi et al.
patent: 4518602 (1985-05-01), Terao et al.
patent: 4563446 (1986-01-01), Terao et al.
patent: 4760068 (1988-07-01), Terao et al.
patent: 4902698 (1990-02-01), Cooper
patent: 4929754 (1990-05-01), Nickl et al.
patent: 4997847 (1991-03-01), Ife et al.
Eisert Wolfgang
Heckel Armin
Meade Christopher
Muacevic Gojko
Muller Thomas
Dahler Garth M.
Devlin M-E. M.
Dr. Karl Thomae GmbH
Ivy C. Warren
Raymond R. P.
LandOfFree
Arylsulphonamides, pharmaceutical compositions containing these does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Arylsulphonamides, pharmaceutical compositions containing these , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylsulphonamides, pharmaceutical compositions containing these will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1027320