Arylsulfone compounds as anti-ulcer agents

Details Arylsulfone compounds as anti-ulcer agents Arylsulfone compounds as anti-ulcer agents

1987-09-14

1989-03-21

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

544392, 544394, 544398, 544403, 564280, 564304, 564347, 564374, 564384, 568 30, C07C 8728, C07C14700

Patent

active

048145076

ABSTRACT:
A novel sulfone compound represented by the general formula (I) ##STR1## wherein R.sup.1 is cyclohexyl, phenyl; or a phenyl substituted with a group selected from nitro, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are respectively hydrogen, halogen, cyano or carbonyl, wherein R.sup.1 and R.sup.2 may form an o-phenylene or an o-phenylene substituted with at least one group selected from nitro C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; X is oxygen or methylkene; Y is -(CH.sub.2).sub.n --, wherein n is an integer of 0, 5 or 6, or ##STR2## wherein m is an integer 1-3; R.sup.6 is hydrogen, C.sub.1 -C.sub.3 alkyl, .omega.-alkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms, or .omega.-dialkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms; R.sup.7 is hydrogen or C.sub.1 -C.sub.3 alkyl; and R.sup.6 and R.sup.7 may form a ring together with N, or ##STR3## wherein R.sup.8 is hydrogen, C.sub.1 -C.sub.3 hydroxyalkyl or phenyl; or a pharmaceutically acceptable salt thereof is disclosed. The compound has anti-ulcer effect.

REFERENCES:
patent: 4734500 (1988-03-01), Tobe et al.
Kikumoto et al, CA 94-57950e (1981).
Kikumoto et al, CA 99-175384z (1983).
Jaachim et al, CA 104-168125j (1986).
Kikumoto et al, J. Med. Chem. 1981, 24(2), 145-8.

Affiliated with

Also associated with

Rating

Arylsulfone compounds as anti-ulcer agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Arylsulfone compounds as anti-ulcer agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylsulfone compounds as anti-ulcer agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-478241