Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1999-07-15
2000-11-28
Celsa, Bennett
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514 15, 514 16, 514 17, 514 18, 514 19, 514 9, 514 11, 514464, 5142388, 514518, 514602, 514604, 549434, 558 56, 558 61, 564 90, A61K 3800
Patent
active
061535850
ABSTRACT:
The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
REFERENCES:
patent: 1955207 (1934-04-01), Stotter et al.
patent: 2358365 (1944-09-01), Tullar
patent: 2402623 (1946-06-01), Hester et al.
patent: 3034955 (1962-05-01), Frick et al.
patent: 4881969 (1989-11-01), Saupe et al.
patent: 4883914 (1989-11-01), Alvarado et al.
patent: 4900867 (1990-02-01), Wilkes et al.
patent: 5143937 (1992-09-01), Lang et al.
patent: 5189211 (1993-02-01), Sato et al.
patent: 5250549 (1993-10-01), Yoshino et al.
patent: 5385931 (1995-01-01), Bigg et al.
patent: 5387709 (1995-02-01), Lardy et al.
patent: 5880151 (1999-03-01), Medina et al.
Fielding et al, "Synthesis and Reactions of 4-sulpho-2,3,5,6-Tetrafluorobenzoic Acid"; Journal of Fluorine Chemistry, vol. 59, No. 1, pp. 15-31 (1992).
Raibekas et al. "Affinity Probing of Flavin Binding Sites. 2. Identification of Reactive cysteine in the Flavin Domain of Escherichia coli DNA Photolyase"; Biochemistry, vol. 33, No. 42, pp. 12656-12664 (1994).
Shealy et al. "2-Haloethylating Agents for Cancer Chemotherapy. 2-Haloethyl Sulfonates"; Journal of Medicinal Chemistry, vol. 26, pp. 1168-1173 (Aug. 1983).
Olander et al., "A Study of the binding of two sulfonamides to Carbonic Anhydrase"; Journal of American Chemical Society, vol. 95, No. 5, pp. 1616-1621 (Mar. 7, 1973).
Hawkinson, et al; "Studies of the Solvolysis of 2-Adamantyl Pentafluorobenzenesulfonate: A Y.sub.PFBS Scale"; The Journal of Organic Chemistry, Aug. 1988, vol. 53, No. 16, pp. 3857-3860.
Chemical Abstracts, vol. 50, No. 1, Jan. 10, 1956 Columbus, Ohio, US; abstract No. 217g, V.O. Lukashevich: "Sulphonation of halogen-substituted benzene derivatives. formation of anhydrides of corresponding sulphonic acids" column 217; XP002083056 see abstract & Doklady Akad. Nauk S.S.S.R., vol. 99, 1954, pp. 995-998.
Chemical Abstracts, vol. 74, No. 14, Apr. 5, 1971, Columbus, Ohio, US; abstract No. 65535a, D. Simov, Et al.: "Preparation of azo dyes containing amobile chlorine atom in the benzene ring" p. 81: XP002083055 see abstract & Izv. Otd. Khim. Nauki, Bulg. Akad. Nauk, vol. 3, No. 1, 1970, pp. 69-82.
I.C. Poppoff, et al.: "Antimalarial agents. 8. Ring-substituted bis-(4-aminophenyl) sulphones and their precursors" Journal of Medicinal Chemistry, vol. 14, No. 12, Dec. 1971, pp. 1166-1169, XP002083052 Washington, FC, US see compounds V, VIII,X, XI, XIII, XVII, XIX, XXVIII, XXXII, XXXVI-XXXVIII, XLI, XLII<XLIV<XLV.
G.E. Chivers, et al.: "Studies in the chemistry of polyhalogenobenzene compounds. The synthesis and reactivity of 2,3,5,6- and 2,3,4,5,-tetrachlorobenzenesulphonyl chlorides and related compounds"; Australian Journal of Chemistry, vol. 29, No. 7, Jul. 1976, pp. 1572-1582, XP002083174, Melbourne, AU.
P.G. DeBenedetti, et al.; "Quantitative structure-activity analysis in dihydropteroate synghase inhibition by sulphones. Comparison with sulphanilamides" Journal of Medicinal Chemistry, vol. 30, No. 3, Mar. 1987, pp. 459-464. XP002083053 Washington, DC, US.
V.N. Babushkin, et al.: "Influence of substituents on the frequency of stretching vibrations of sulphur-containing bridging groups in diphenyl systems" Journal of General Chemistry of the USSR, vol. 58, No. 7, pt. 2, Jul. 1988., pp. 1457-1460. XP002083054 New York, US.
Yoshimoto and Hansch, "Correlation Analysis of Baker's Studies on Enzyme Inhibition. 2. Chymotrypsin, Thymidine Phosphorylase, Uridine Phosphorylase, Thymidylate Synthetase, Cytosine Nucleoside Deaminase, Dihydrofolate Reductase, malate Dehydrogenase, Glutamate Dehydrogenase, Lactate Dehydrogenase, and Glyceraldehyde-phosphate Dehydrogenase."; Journal of Medicinal Chemistry (1976) vol. 19, No. 1 pp. 71-98.
Bai, et al.; "Identification of the cystein Residue of .beta.-Tubulin Alkylated by the Antimitotic Agent 2,4-Dichlorobenzyl Thiocyanate, Facilitated by Separationof the Protein subunits of Tubulin by Hydrophobic column chromatography"; Biochemistry 1989, vol. 28, pp. 5606-5612.
Jaen Juan C.
Rubenstein Steven M.
Celsa Bennett
Tularik Inc.
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