Arylsulfonamido-substituted hydrodxamic acids

Details Arylsulfonamido-substituted hydrodxamic acids Arylsulfonamido-substituted hydrodxamic acids

1996-03-11

1997-09-30

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142378, 514311, 514331, 514332, 514341, 514365, 514396, 514406, 514432, 514445, 514451, 514602, 514604, 540524, 540531, 544 581, 544168, 544130, 544131, 544133, 546175, 546194, 546209, 546247, 546265, 5462834, 5462821, 546333, 546337, 5462804, 5462844, 5462817, 5462751, 548205, 5483351, 5483381, 549 13, 549 65, 549426, 564 84, 564 90, 564 92, 564 94, C07D21342, A61K 3144

Patent

active

056726155

ABSTRACT:
Disclosed are the compounds of formula I ##STR1## wherein R and R.sub.1 together with the chain to which they are attached or R.sub.1 and R.sub.2 together with the carbon atom to which they are attached form a ring; pharmaceutically acceptable prodrug derivatives and pharmaceutically salts thereof; methods of preparation thereof; pharmaceutical compositions comprising said compounds; and a method of inhibiting matrix-degrading metalloproteinase and of treating matrix-degrading metalloproteinase dependent conditions in mammals using such compounds.

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