Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1992-01-29
1993-12-14
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435886, C12N 916
Patent
active
052701964
ABSTRACT:
The present invention relates to an arylsulfatase of microbial origin. The enzyme may be linked to an antibody against a tumor-associated antigen and the resulting conjugate used in conjuction with a sulfated prodrug of a 4'-demethylepipodophyllotoxin glucoside derivative, particularly etoposide in cancer chemotherapy.
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Fukagawa Yasuo
Oki Toshikazu
Sawada Yosuke
Tomita Koji
Ueki Tomokazu
Bristol--Myers Squibb Company
Robinson Douglas W.
Saucier S.
Yang Mollie M.
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