Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-06-24
1996-04-09
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142378, 514311, 514331, 514332, 514341, 514365, 514396, 514406, 514432, 514445, 514451, 514602, 514604, 546175, 546247, 546283, 546265, 546276, 546336, 546337, 544168, 548205, 5483351, 5483381, 549 13, 549 65, 549426, 564 84, 564 90, 564 92, 564 94, A61K 3144, C07D40306
Patent
active
055062423
ABSTRACT:
The invention relates to a method of inhibiting metalloellastase activity, of inhibiting the degradation of elastin, or of treating macrophage metalloelastase dependent conditions in mammals which comprises administering to a mammal in need thereof an effective macrophage metalloelastase inhibiting amount of a compound of formula I ##STR1## wherein Ar, R, R.sub.1 and R.sub.2 have meanings as defined, or of a pharmaceutically acceptable prodrug derivative thereof, or of a pharmaceutically acceptable salt thereof, or of pharmaceutical compositions comprising a said compound.
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Jeng Arco Y.
MacPherson Lawrence J.
Parker David T.
Ciba-Geigy Corporation
Davis Zinna N.
Gruenfeld Norbert
Ivy C. Warren
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