Arylpyrazoles as leukotriene inhibitors

Details Arylpyrazoles as leukotriene inhibitors Arylpyrazoles as leukotriene inhibitors

1997-11-24

1998-12-01

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546174, 546175, 546176, 5483771, A61K 3147, C07D40112

Patent

active

058439587

ABSTRACT:
Compounds of Formula I ##STR1## useful in the treatment of inflammatory disorders.

REFERENCES:
patent: 4898952 (1990-02-01), Murray et al.
Structure-Activity Relatinships in the Quinoline-Containing Class of Inhibitors of 5-Lipoxygenase Enzyme Translocation and Activation, A.F. Freft, L.A. Marshall, and A. Wong, Drugs of the Future, 1994, 19(3): 255.
5-Lipoxygenase: Properties, Pharmacology, and the Quinolinyl(Bridged)Aryl Class of Inhibitors, J.H. Musser and A. F. Kreft, J. Med. Chem., vol. 35, No. 14, 2501 (1992) and references therein.
A New Class of Leukotriene Biosynthesis Inhibitors: THe Discovery of MK0591, P. Prasit, M. Belley, C. Brideau, C. Chan, S. Charleson, J.F. Evans, R. Fortin, A. W. Ford-Hutchinson, S. Leger, D. Riendeau, R. N. Young, and R. Zamboni, Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 12, 1699, 1992.
Development of L-689, 065--The Prototype of a New Class of Potent 5-Lipoxygenase Inhibitors, J. H. Hutchinson, P. Prasit, L. Y. Choo, D. Riendeau, S. Charleson, J. F. Evans, H. Piechuta, G. G. Ball, Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 12, 1699, 1992.
Flap: A Novel Drug Target for Inhibiting the Synthesis of Leukotrienes, A. W. Ford-Hutchinson, Trends Pharmacol. Sci., 12, 68 (1991).
A New Class of Leukotriene Biosynthesis Inhibitors: The Development of ((4-(-Chlorophenyl)-1-(4-(2-Quinolylmethoxy)Phenyl)Butyl)Thio)Acetic Acid, L-674, 636, P. Prasit, M. Belley, J. F. Evans, J. Y. Gauthier, C. Leveille, C. S. McFarlane, E. MacIntyre, L. Peterson, H. Piechuta, M. Therien, R. N. Young, and R. Zamboni.
Discovery of Inhibitors of the 5-Lipoxygenase Activating Protein (Flap), R. N. Young, J. W. Jillard, J. H. Hutchinson, S. Leger, and P. Prasit, Can. J. Lipid Mediators, (1993), 6 (1-3), 2338.
Clinical and Biochemical Effects of an Oral Leukotriene Biosynthesis Inhibitor (MK886) in Psoriasis, Skin Pharmacol 1991; 4:278-285, E. M. G. J. DeJong, I.M.M. J. Van Vlijmen, J.C. M. Scholte, A. Buntinx, B. Friedman, W. Tanaka, P. C. M. Van De Kerkhof.

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