Arylpyrazoles as leukotriene inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

3483771, C07D40114

Patent

active

058696741

ABSTRACT:
Compounds of Formula I ##STR1## useful in the treatment of inflammatory disorders.

REFERENCES:
patent: 4898952 (1990-02-01), Murray et al.
Structure-Activity Relationships in the Quinoline-Containing Class of Inhibitors of 5-Lipoxygenase Enzyme Translocation and Activation, A.F. Freft, L.A. Marshall, and A. Wong, Drugs of the Future, 1994, 19(3): 255.
5-Lipoxygenase: Properties, Pharmacology, and the Quinolinyl (Bridged) Aryl Class of Inhibitors, J.H. Musser and A. F. Kreft, J. Med. Chem., vol. 35, No. 14, 2501 (1992) and references therein.
A New Class of Leukotriene Biosynthesis Inhibitors: The Discovery of MK0591, P. Prasit, M. Belley, C. Brideau, C. Chan, S. Charleson, J.F. Evans, R. Fortin, A. W. Ford-Hutchinson, S. Leger, D. Riendeau, R. N. Young, and R. Zamboni, Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 12, 1699, 1992.
Development of L-689,065--The Prototype of a New Class of Potent 5-Lipoxygenase Inhibitors, J. H. Hutchinson, P. Prasit, L. Y. Choo, D. Riendeau, S. Charleson, J. F. Evans, H. Piechuta, G. G. Ball, Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 12, 1699, 1992.
Flap: A Novel Drug Target for Inhibiting the Synthesis of Leukotrienes, A. W. Ford-Hutchinson, Trends Pharmacol. Sci., 12, 68 (1991).
A New Class of Leukotriene Biosynthesis Inhibitors: The Development of ((4-(Chlorophenyl)-1-(4-(2-Quinolylmethoxy)Phenyl)Butyl)Thio)Acetic Acid, L-674,636, P. Prasit, M. Belley, J. F. Evans, J. Y. Gauthier, C. Leveille, C. S. McFarlane, E. MacIntyre, L. Peterson, H. Piechuta, M. Therien, R. N. Young, and R. Zamboni.
Discovery of Inhibitors of the 5-Lipoxygenase Activating Protein (Flap), R. N. Young, J. W. Jillard, J. H. Hutchinson, S. Leger, and P. Prasit, Can. J. Lipid Mediators, (1993), 6 (1-3), 2338.
Clinical and Biochemical Effects of an Oral Leukotriene Biosynthesis Inhibitor (MK886) In Psoriasis, Skin Pharmacol 1991; 4:278-285, E. M. G. J. DeJong, I.M.M. J. Van Vlijmen, J.C. M. Scholte, A. Buntinx, B. Friedman, W. Tanaka, P. C. M. Van De Kerkhof.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Arylpyrazoles as leukotriene inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Arylpyrazoles as leukotriene inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylpyrazoles as leukotriene inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1949887

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.