Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2009-10-05
2010-11-30
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S381000, C514S400000, C548S335500, C548S250000, C548S311100
Reexamination Certificate
active
07842708
ABSTRACT:
The present invention provides compounds of Formula (I):or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L1, M and R11are as defined herein. The compounds of Formula (I) are selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
REFERENCES:
patent: 6852725 (2005-02-01), Thurieau et al.
patent: 7129264 (2006-10-01), Smallheer et al.
patent: 7138412 (2006-11-01), Quan et al.
patent: 7238695 (2007-07-01), Thurieau et al.
patent: 7417063 (2008-08-01), Smallheer et al.
patent: 7429604 (2008-09-01), Corte et al.
patent: 7453002 (2008-11-01), Hangeland et al.
patent: 7459564 (2008-12-01), Corte et al.
patent: 2004/0132788 (2004-07-01), Chabrier de Lassauniere
patent: 2004/0180855 (2004-09-01), Schumacher et al.
patent: 2004/0186151 (2004-09-01), Mjalli et al.
patent: 2005/0049283 (2005-03-01), Eckl et al.
patent: 2005/0203143 (2005-09-01), Breslin et al.
patent: 2006/0004013 (2006-01-01), Kimura et al.
patent: 2009/0062287 (2009-03-01), Corte
patent: 2009/0181983 (2009-07-01), Corte
patent: WO 98/27108 (1997-11-01), None
patent: WO 99/64401 (1999-12-01), None
patent: WO 01/02387 (2001-01-01), None
patent: WO 0102387 (2001-01-01), None
U.S. Appl. No. 12/097,068, Wei Han.
Cavallaro Cullen L.
Corte James R.
Gilligan Paul J.
Hu Zilun
Pinto Donald J. P.
Bristol--Myers Squibb Company
Rodriguez-Garcia Valerie
Saeed Kamal A
Sun Jing G.
LandOfFree
Arylpropionamide, arylacrylamide, arylpropynamide, or... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Arylpropionamide, arylacrylamide, arylpropynamide, or..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylpropionamide, arylacrylamide, arylpropynamide, or... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4251951