Aryloxyalkylamine NK-1/SSRI inhibitors

Details Aryloxyalkylamine NK-1/SSRI inhibitors Aryloxyalkylamine NK-1/SSRI inhibitors

2007-02-20

2007-02-20

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C564S340000, C564S346000, C564S367000, C514S438000, C514S649000, C514S651000, C514S654000

Reexamination Certificate

active

11188581

ABSTRACT:
The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.

REFERENCES:
patent: 6136824 (2000-10-01), MacLeod et al.
patent: 6441237 (2002-08-01), Stransky et al.
patent: WO 2004/005255 (2004-01-01), None
patent: WO 2004/005256 (2004-01-01), None
Database CAPLUS on STN, Acc. No. 2000:592689, Stransky et al., WO 2000048987 A1 (Aug. 24, 2000) (abstract).
T. Ryckmans, et al, “First Dual NK1, Antagonists-Serotonin Reuptake Inhibitors: Synthesis and SAR of a New Class of Potential Antidepressants,” Bioorganic & Medicinal Chemistry Letters, 12, pp. 261-264, 2002.
R. M. Shafik, et al, “Synthesis and Biochemical Evaluation of 2-Arylpropane-1,3-Diamines: Potential Bilateral Diamino Dopaminergic Analogs,” Alexandria Journal of Pharmaceutical Sciences, 2(2), pp. 155-160, 1988—Database CAPLUS on STN, Acc. No. 1989:614161.

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