Aryloxy propyldiamines

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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42424856, 424250, 424274, 424330, 546206, 546191, 2603265C, 260349, 2605707, 544 79, 544121, 544129, 544141, 544357, 544372, 544398, C07D29512, A61K 31455

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active

041407792

ABSTRACT:
Disclosed herein are compounds of the formula ##STR1## in which Ar is l-naphthyl; R.sup.1 and R.sup.2 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are joined form a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidine, morpholine and 4-(lower alkyl)-1-piperazinyl; and R.sup.3 and R.sup.4 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R.sup.3 and R.sup.4 together with the nitrogen to which they are joined represent a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl; or a therapeutically acceptable acid addition salt thereof. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.

REFERENCES:
dauksas et al., Zh. Vscs. Khim. Obshchestva im. D. I. Meadeleeva, 9(3), pp. 352-354, (1964); Chem. Abstracts 61:6942c, (1964).
Cram et al., "Organic Chemistry", McGraw-Hill, New York, pp. 255 and 257.

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