Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-20
2000-09-26
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544254, C07D48704, A61K 31505
Patent
active
061243000
ABSTRACT:
Novel compounds and pharmaceutical compositions thereof, and methods of using same in treating anxiety, depression, and other psychiatric and neurological disorders. The novel compounds provided by this invention are those of the following formulae: ##STR1## wherein R.sup.1, R.sup.13, X, Y, Z, G and Q are as defined herein.
REFERENCES:
patent: 4076711 (1978-02-01), GaNguly et al.
patent: 4916224 (1990-04-01), Vince et al.
Chalmers et al. TiPS vol. 17, pp. 166-172, Apr. 1996.
Higashino et al. (heterocycles (1981), 15(1), 483-7).
Higashino et al. (Fukusokan Kagaku Toronkai Koen Yoshishu, 12th (1979), 171-5).
Higashino et al. (Chem. Pharm. Bull. (1980), 28(1), 337-43.
Higashino et al. Yakugaku Zasshi (1979), 99(10), 1031-6).
Stratakis et al. (Chapter 13), 1997.
Rivier et al., Proc. Nat'l. Acad. Sci., vol. 80, p. 4851 (1983).
W. Vale et al., Science, vol. 213, p. 1394 (1981).
W. Vale et al., Recent Progress in Hormone Research, vol. 39, p. 245 (1983).
G.F. Koob, Persp. Behav. Med., vol. 2, p. 39 (1985).
E.B. DeSouza et al., Journal of Neuroscience, vol. 5, p. 3189 (1985).
J.E. Blalock, Physiological Reviews, vol. 69, p. 1 (1989).
J.E. Morley, Life Science, vol. 41, p. 527 (1987).
E.B. DeSouza, Hospital Practice, vol. 23, p. 59, (1988).
C.B. Nemeroff et al., Science, vol. 226, p. 1342 (1984).
C.M. Banki et al., American Journal of Psychiatry, vol. 144, p. 873 (1987).
R.D. France et al., Biol. Psychiatry, vol. 23, p. 86 (1988).
M. Arato et al., Biol. Psychiatry, vol. 25, p. 355 (1989).
C.B. Nemeroff et al., Arch. Gen. Psychiatry, vol. 45, p. 577 (1988).
P.W. Gold et al., American Journal of Psychiatry, vol. 141, p. 619 (1984).
F. Holsboer et al., Psychoneuroendocrinology, vol. 9, p. 147 (1984).
P.W. Gold et al., New England Journal of Medicine, vol. 314, p. 1129 (1986).
R.M. Sapolsky, Arch. Gen. Psychiatry, vol. 46, p. 1047 (1989).
Grigoriadis et al., Neuropsychopharmacology, vol. 2, p. 53 (1989).
D.R. Britton et al., Life Science, vol. 31, p. 363 (1982).
C.W. Berridge and A.J. Dunn, Regul. Peptides, vol. 16, p. 83 (1986).
C.W. Berridge and A.J. Dunn, Horm. Behav., vol. 21, p. 393 (1987).
C.W. Berridge and A.J. Dunn, Brain Research Reviews, vol. 15, p. 71 (1990).
K.T. Britton et al., Psychopharmacology, vol. 86, p. 170 (1985).
K.T. Britton et al., Psychopharmacology, vol. 94, p. 306 (1988).
N.R. Swerdlow et al., Psychopharmacology, vol. 88, p. 147 (1986).
G.F. Koob and K.T. Britton, Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide, p. 221 (1990).
Tanji et al., Chem. Pharm. Bull., vol. 39, p. 3037-3040 (1991).
Settimo et al., Il Farmaco, Ed. Sc., vol. 35, p. 308-323 (1980).
Biagi et al., Il Farmaco, vol. 49, p. 183-186 (1994).
Thompson et al., J. Med. Chem., vol. 34, p. 2877-2882 (1991).
Kelley et al., J. Med. Chem., vol. 31, pp. 606-612 (1990).
Kelley et al., J. Med. Chem., vol. 33, pp. 1360-1363 (1990).
Kelley et al., J. Heterocyclic Chem., vol. 28, p. 1099 (1991).
Khairy et al., J. Heterocyclic Chem., vol. 22, p. 853 (1985).
Remington's Pharmaceutical Sciences, 17.sup.th ed., Mack Publishing Co., Easton, PA, p. 1418 (1985).
P.J. Munson and D. Rodbard, Anal. Biochem., vol. 107, p. 220 (1980).
G. Battaglia et al., Synapse, vol. 1, p. 572 (1987).
Kaiwar et al., J. Chem. Soc., Perkin Trans. 1, pp. 2281-2287 (1995).
Kohda et al., Biological Pharm. Bull., vol. 18, No. 3, pp. 424-430 (1995).
Buck et al., Tetrahedron, vol. 50, No. 30, pp. 9195-9206 (1994).
Chae et al., J. Med. Chem., vol. 37, pp. 342-347 (1994).
Krenitsky et al., J. Med. Chem., vol. 32, pp. 1471-1475, (1989).
Ronisvalle et al., Il Farmaco, vol. 44, No. 4, pp. 383-390 (1989).
Harnden et al., J. Med. Chem., vol. 32, pp. 1738-1743, (1989).
Ukena et al., FEBS Letters, vol. 215, No. 2, pp. 203-208 (May 1987).
Drawbaugh et al., J. Med. Chem., vol. 19, No. 11, pp. 1342-1345 (1976).
Israel et al., J. Het. Chem., vol. 8, No. 6, pp. 1019-1023 (1971).
Chem. Abstr., vol. 123, No. 25, Dec. 18, 1995, p. 1249, col. 2, the Abstract No. 340767a, Reese C., EP664, 294, Jan. 19, 1994.
Chem. Abstr., vol. 120, No. 21, May 23, 1994, p. 398, col. 1, the abstract No. 263837g, Shibata, T., JP 9401793, Jun. 18, 1992.
Chem. Abstr., vol. 117, No. 1, Jul 6, 1992, p. 799, col. 1, the abstract No. 7889q, El-Bayouki, K.A.M., An Quim. 1991, 87(7), 899-902.
Chem. Abstr., vol. 111, No. 9, Aug. 28, 1989, p. 736, the abstract No. 77826, Bois-Choussy, M., Eur. J. Med. Chem. 1988, 23(6), 539-546 (Fr).
Chem. Abstr., vol. 101, No. 9, Aug. 27, 1984, p. 647, col. 2, the abstract No. 72754a, S.S. Pharmaceutical Co., JP 84 62,595, Apr. 10, 1984.
Chem. Abstr., vol. 96, No. 15, Apr. 12, 1982, p. 705, col. 1, the abstract No. 122819b, S.S. Pharmaceutical Co., JP 81, 131, 587, Oct. 15, 1981.
Chem. Abstr., vol. 96, No. 9, Mar. o1, 1982, p. 616, col. 2, the abstract No. 69024k, S.S. Pharmaceutical Co., JP 81, 131, 586, Oct. 15, 1981.
Chem. Abstr., vol. 89, No. 13, Sep. 25, 1978, pp. 357-358, col. 2, the Abstract No. 102934n, Breter, H., Biocheim. Biophys. Acta, 1978, 518(2), 205-15 (Eng).
Chem. Abstr., vo. 87, No. 3, Jul. 18, 1977, p. 639, col. 7, the abstract No. 23126f, Arya, V.P., Indian J. Chem., Sect. B 1976, 14B(10), 756-8 (Eng).
Chem. Abstr., vol. 77, No. 19, Nov. 6, 1972, p. 6 col. 2, the abstract No. 121989c, Niebch, G., Z. Naturforsch. B 1972, 27(6), 675-82 (Ger).
Chalmers et al., TIPS, vol. 17, pp. 166-172.
Higashino et al., Heterocycles, vol. 15(1), p. 483-7 (1981).
Higashino et al., Fukusokan Kagaku Toronkai Koen Yoshishu, 12.sup.th, p. 171-5 (1979).
Higashino et al., Chem Pharm. Bull., vol. 28(1), pp. 337-43 (1980).
Higashino et al., Yakugaku Zasshi, vol. 99(10), p. 1031-6 (1979).
Stratakis et al., Endocrinology: Basic and Clinical Principles, Chapter 13, Humana Press Inc., NJ (1997).
LaRock, Comprehensive Organic Transformations, VCH Publishers, NY, p. 411 (1989).
Bakthavatchalam Rajagopal
Beck James Peter
Chorvat Robert John
Gilligan Paul Joseph
Olson Richard Eric
Dupont Pharmaceuticals
Kifle Bruck
O'Brien Maureen P.
Rubin Kenneth B.
Shah Mukund J.
LandOfFree
Aryloxy- and arylthio- fused pyridines and pyrimidines and deriv does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aryloxy- and arylthio- fused pyridines and pyrimidines and deriv, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aryloxy- and arylthio- fused pyridines and pyrimidines and deriv will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2100436