Aryloxy and arylacyloxy methyl ketones as thiol protease inhibit

Details Aryloxy and arylacyloxy methyl ketones as thiol protease inhibit Aryloxy and arylacyloxy methyl ketones as thiol protease inhibit

1987-12-07

1991-10-08

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514 18, 530330, 530331, 560 10, 560 18, 560 37, 560 45, 560 80, 560100, 560110, 562445, 562448, 562556, 562564, 562567, A61K 3702, C07K 506, C07K 508, C07K 510

Patent

active

050554514

ABSTRACT:
Thiol protease inhibitors are disclosed having the formula: ##STR1## or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein:

REFERENCES:
patent: 4539312 (1985-09-01), Delaney et al.
patent: 4636492 (1987-01-01), Kettner et al.
patent: 4652552 (1987-03-01), Kettner et al.
patent: 4692552 (1987-09-01), Mueller et al.
patent: 4820691 (1989-04-01), Patel
CA 65: 8822(e), vol. 65 (1966).
CA 97(22): 188158n.
CA 66(7): 29056w.
Ahmed, A. K. S., et al., J. Pharm. Belg. (1982), vol. 37, No. 3, pp. 214-217.
Muramatsu, N., Bull. Chem. Soc. Japan (1966), vol. 39, No. 6, pp. 1273-1279.

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