(Arylmethyl)phenyl-aminocyclohexanols, cyclohexenes and intermed

Details (Arylmethyl)phenyl-aminocyclohexanols, cyclohexenes and intermed (Arylmethyl)phenyl-aminocyclohexanols, cyclohexenes and intermed

1981-04-27

1982-02-02

Breitenstein, G. T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2603409R, 564265, 564300, 564307, 568322, 568329, A61K 31315, C07C 9116, C07C 8736

Patent

active

043139590

ABSTRACT:
(Arylmethyl)phenyl-aminocyclohexanols, (arylmethyl)phenyl aminocyclohexenes and (arylmethyl)phenyl-aminocyclohexanes and methods of preparing same are described. These compounds are useful as antidepressants and anticonvulsants.
Compounds 8-[2-(phenylmethyl)phenyl]-1,4-dioxaspiro[4,5]-decan-8-ol, 1-[2-(phenylmethyl)phenyl]-4-oxocyclohexanol, and 1-[2-(phenylmethyl)phenyl]-4-oxocyclohexanol oxime, and methods of preparing same are also described. These compounds are useful as intermediates for preparing the antidepressant and anticonvulsant compounds.

REFERENCES:
patent: 3652769 (1972-03-01), Saari
patent: 4028415 (1977-06-01), Clark
Lednicer et al., J. of Medicinal Chemistry, vol. 15, No. 12, 1235-1238, (1972).
Lednicer et al., J. of Medicinal Chemistry, vol. 15, No. 12, 1239-1243, (1972).
Carmalm et al., Chem. Absts., 83, 157704(a), 1975.
Carenini et al., Chem. Absts., 80, 47509(q), 1974.

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