Arylmalonamidomethoxycephalosporins

Details Arylmalonamidomethoxycephalosporins Arylmalonamidomethoxycephalosporins

1977-07-28

1980-05-20

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 21, C07D50136

Patent

active

042039827

ABSTRACT:
Antibacterial 7.beta.-arylmalonamido-7.alpha.-methoxy-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids of the formula: ##STR1## wherein Ar is a heterocyclic group or p-oxysubstituted phenyl; COB.sup.1 and COB.sup.2 are each a carboxy or protected carboxy group; and Het is an unsubstituted or substituted heterocyclic group. These compounds are prepared from, e.g., 7.beta.-amino-7.alpha.-methoxy-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives by acylation with arylmalonic acid or reactive derivatives thereof. They are useful as an active ingredient in antibacterial pharmaceutical preparations.

REFERENCES:
patent: 3641021 (1972-02-01), Ryan
patent: 3962232 (1976-06-01), Koppel
patent: 3989694 (1976-11-01), Berges
patent: 3993758 (1976-11-01), Burton et al.
patent: 4041029 (1977-08-01), Firestone et al.
patent: 4068073 (1978-01-01), Berges

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