Arylkylamine spirofuropyridines useful in therapy

Details Arylkylamine spirofuropyridines useful in therapy Arylkylamine spirofuropyridines useful in therapy

2006-02-07

2006-02-07

Stockton, Laura L. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S018000

Reexamination Certificate

active

06995167

ABSTRACT:
A compound of formula I,wherein NRR1is attached at the 5- or 6-position of the furopyridine ring; R is hydrogen, C1–C4alkyl, or COR2; R1is (CH2)nAr, CH2CH═CHAr, or CH2C≡CAr; n is 0 to 3; A is N or NO; Ar is a 5- or 6-membered aromatic or heteroaromatic ring which contains zero to four nitrogen atoms, zero to one oxygen atoms, and zero to one sulfur atoms; or an 8-, 9- or 10-membered fused aromatic or heteroaromatic ring system containing zero to four nitrogen atoms, zero to one oxygen atoms, and zero to one sulfur, any of which may optionally be substituted with one to two substitutents independently selected from: halogen, trifluoromethyl, or C1–C4alkyl; R2is hydrogen, C1–C4alkyl, C1–C4alkoxy or phenyl ring optionally substituted with one to three of the following substituents: halogen, C1–C4alkyl, C2–C4alkenyl, C2–C4alkynyl, OH; OC1–C4alkyl, CO2R5, —CN, —NO2, —NR3R4, or —CF3; R3, R4and R5may be hydrogen, C1–C4alkyl, or phenyl ring optionally substituted with one to three of the following substituents: halogen, C1–C4alkyl, C2–C4alkenyl, C2–C4alkynyl, OH; OC1–C4alkyl, —CN, —NO2, or —CF3; and enantiomers thereof, and pharmaceutically acceptable salts thereof, processes for preparing them, composition containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.

REFERENCES:
patent: 6110914 (2000-08-01), Phillips et al.
patent: 6706878 (2004-03-01), Phillips et al.
patent: 0 311 131 (1989-04-01), None
patent: WO 9606098 (1996-02-01), None
patent: WO 9705139 (1997-02-01), None
patent: WO 97/41125 (1997-11-01), None
CAS ONLINE display of structures 1-87 from WO 9903859, Phillips et al. Dec. 8, 1999.
J. Med Chem vol. 39, 1996, Gunnar Nordvall et al, “3-(2-Benzofuranyl)quinclidin-2-ene Derivatives: Novel Muscarinic Antagonists”, p. 3269-3277, compound 9.

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