Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-10-25
2005-10-25
Desai, Rita (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C546S111000
Reexamination Certificate
active
06958328
ABSTRACT:
This invention provides novel arylindenopyridines of the formula:, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
REFERENCES:
patent: 6063788 (2000-05-01), Brandes et al.
patent: 0825185 (1998-02-01), None
patent: 2001 139556 (2001-04-01), None
patent: WO 94/09002 (1994-04-01), None
patent: WO 99/03846 (1999-01-01), None
patent: WO 00/42019 (2000-07-01), None
patent: WO 00/68230 (2000-11-01), None
patent: WO 01/21621 (2001-03-01), None
patent: WO 93 08167 (2001-04-01), None
patent: WO 01 62233 (2001-08-01), None
patent: WO 02 085894 (2002-10-01), None
patent: WO 03 088963 (2003-10-01), None
Ulrich Rose, 1990, “5-oxo-1,4-dihydroindenopyridines: calcium modulators . . ”, CAS:113:78100.
Copy of PCT Search Report dated Aug. 27, 2002, for PCT International Application No. PCT/US02/11823.
Afsah, E.M. et al.: “Introduction of some phamaceuticially active heterocycles into the benzylic moiety of 2-benzyl-1,3-indandione”; Pharmazie 45 (1990), H.4, pp. 255-257.
Bocker, R.H. et al.: “Oxidation of 4-Aryl-and 4-Alkyl-Substituted 2,6-Dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by Human Liver Microsomes and Immunochemical Evidence for the Involvement of a Form of Cytochrome P-450”; J. Med. Chem. 1986, 29, pp. 1596-1603.
Bradley, G. et al.: “2,3-Dihydroquinolin-4(1H)-ones. Part I. Halogen-substituted 2,3-Di-hydroquinolin-4(1H)-ones and their 1-(2-Acylethyl) Derivatives”; J. Chem. Soc., Perkin Trans. 1, 1972, pp 2019-2023.
Bullington, J.L. et al.: “The Development of NOvel and Selective p56ck Tyrosine Kinase Inhibitors1”; Bioorg. Med. Chem. Lett. 1998, 8, pp. 2489-2494.
Chatterjea, J.N. et al.; “Synthesis in the 4-Azafluorene Group. Part III”; J. Indian Chem. Soc., vol. LV, 1978, pp. 149-153.
Gorlitzer, K. et al.: “Indeno[1,2-b]pyridin-4-yl-amine3”; Pharmazie 52 (1997) 7, pp. 504-510.
Jursic, B.S. et al.: “A Simple Preparation of Amides from Acids and Amines by Heating of their Mixture”; Synthetic Comm. 1993, 23, pp. 2761-2770.
Kobayashi, T. et al: “Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. I. Synthesis and Antihypertensive Effects of 2-Amio-1,4-dihydropyridine Derivatives Having Nitroxyalkoxycarbonyl Groups at 3- and/or 5-Position”; Chem. Pharm. Bull. 1995, 43, pp. 788-796.
Li, L. et al.: “CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation”; Science, Feb. 5, 1999, vol. 283, pp. 848-851.
Lusis, V. et al.: “Synthesis and Isomerization of 1H-4,4a,5,9b-Tetrahydroindeno-[1,2-b]pyridines”; Tetrahedron 1991, vol. 47, No. 35, pp. 7429-7436.
Martinez, A. et al.: “Benzyl Derivatives of 2,1,3-Benzo- and Benzothieno[3,2-a]thiadiazine 2,2-Dioxides: First Phosphodiesterase 7 Inhibitors”; J. Med. Chem. 2000, 43, pp. 683-689.
Ogawa, T. et al.: “Synthesis and Configurational Assignment of Methyl 3Nitrooxypropyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate”; J. Chem. Soc. Perkin Trans. 1 1993, pp. 525-528.
Omuaru, V.O.T.: “Reactions of cyclic anhydrides with aromatic primary amines: Part 3—Synthesis of novel 3-(N-arylcarbamoyl)- and 3-(N-naphthylcarbamoyl)carboxylic acids”; Indian J. of Chem. Sect. B. 1998, 37, pp. 814-816.
Petrow, V. et al.: “New Synthesis of Heterocyclic Compounds. Part X. 4-Azafluorenones”, JCS, 1949, pp. 2134-2139.
Reddy, A.S. et al.: “A convenient method for the preparation of hydroxamic acids”; Tetrahedron Letters 41 (2000), pp. 6285-6288.
Rose, U.: “5-Oxo-1,4-dihydroindenopyridines: Calcium Modulators with Partial Calcium Agonistic Activity”; J. Heterocyclic Chem., 27, (1990), pp. 237-242.
Sausin'sh, A. et al.: “Methods for the Synthesis of 4-Pyrazolyl- and 4-Pyridyl-5-Oxo-1,4,5,7-Tetrahydrofuro[3,4-b]Pyridines”; Chem. of Heterocyclic Compounds, vol. 31, No. 7, 1995, pp. 841-846.
Vanden Eynde, J.J. et al.: “Old Reagents, New Results: Aromatization of Hantzsch 1,4-Dihydropyridines awith Manganese Dioxide and 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone.”; Tetrahedron vol. 51, No. 23 (1995), pp. 6511-6516.
Vigante, B. et al.: Latv. PSR Zinat. Akad. Vestis, Kin. Ser. 1980, p. 707-175.
Vigante, B.A. et al.: “Infrared Absorption of 4,5-Dihdroindeno[1,2-b]Pyridines”; Chem. Het. Compounds, 25(5) 1989, pp. 524-527.
Weissman, S.A. et al.: “Efficient Synthesis of N-Arylpiperazinones via a Selective Intramolecular Mitsunobu Cyclodehydration”; Tetrehedron Lett. 1998, 39, pp. 7459-7462.
Zandersons, A. et al.: “Synthesis of 5-Oxoindeno[1,2-b]Pyridinium Salts”; Chem. Het. Compounds 22(1), 1986, pp. 73-76.
Zimmer, H. et al.: “Substituted y-Lactones. 28.13-(Phenylmethylene)-2,4(3H,5H)-furandiones”; J. Org. Chem. vol. 43, No. 8, 1978, pp. 1541-1544.
Chemical Abstracts, vol. 59, No. 6, Sep. 1963; XP-002211132.
El-Tawell F. M. A. et. al.: “Synthetic Routes to Fluorenone, Indenopyiroine, 4H-Naphthoa2, 1-Bupyrans and Pyridine Derivaties”, Bolettino Chimico Farmaceutico, Societa Editoriate Farmaceutica, Milano, Italy, vol. 140, No. 5, 2001, pp. 306-310, XP009025181, ISSN: 0006-6848 See compound 14.
Goerlitzer K. et al: “IndenoA1, 2-Dupyrimidin-4-YL-Amine IndenoA1, 2upyrimidin-4-YL-Amines” Pharmazie, Veb Varleg Volk Und Gesundheit. Berlin, DD vol. 52, No. 9, 1997 pp. 670-672, XP001179310, ISSN: 0031-7144 see compounds 3, 6-8 and whole article, especially 2.2.1.
Burger K. et. al. “Trifluormethyl-Substituierte Pryimidine Aus Enaminen Und Trifluoracetonitril Trifluoromethyl-Substituted Pyrimidines from Enamines and Trifluoroacetonitrile” Liebigs Annalen Der Chemie, Verlag Chemie GMBH Weinheim, DE, vol. 5, 1964, pp. 991-1002 XP001179309 ISSN:0170-2041 see compund 18a.
Demerac S. et. al., “5H-IndenoA1, 2-Dupyrumidin-5-Ones” Austrailian Journal of Chemistry, XX, XX, vol. 25, 1972, pp. 2651-2657, XP009025111 issn: 0004-9425 see compounds 5a-5e and 9-11.
Augustin, M.: “Synthese Und Reaktionen Von 2-Abis- (Alklthio)-Methlidenu-Indan-1, 3-Dionen Synthesis and Reactions of 2-Abis-(Alkylthio)-Methlidenu-Indan-1,3-Dion”, Journal Fuer Praktische Chemie, Wiley WeinHeim, DE, vol. 321, No. 2, 1979, pp. 205-214, XP009025100, ISSN: 1436-9966, see 11b, p. 212 and 11c, p213.
N El-Rayyes; “Heterocycles. 14. Sythesis of 5H-Indenopyrumidines” J. Chem. Eng. Data, vol. 32, 1967, pp. 481-483, XP002270517 see formula VII, f,h,j, Va-k.
Kappe C. O. et. al. “Sythesis and Reactions of Biginelli-Compounds. Part I” Journal of Heterocyclic Chemistry, Heterocorporation Provo, US, Jan. 1989, pp. 55-64, XP002952094, ISSN: 00220152X, see compound 29a.
A. Rosowsky; “One Step Sythesis of Nove 2, 4-Diaminopyrumudube Antifolates” J. Heterocyclci Chemistry vol. 36, 1999, pp. 723-728, XP002270518 see 20(14).
Kandeel, E.M. et. al.: “Sythnesis of New 1,2-Dihydro-4-Amino-2-Thioxo-5H-Indeno 1,2-D Pyrimidin-5-One Derivaties” Pakistan Journal of Scientific and Industrial Research, XX, XX, vol. 29, No. 6, Dec. 1988 pp. 424-426, XP009025187 ISSN: 0030-9885 see V1a, V1b, Va, Vb.
PCT Search Report dated Jan. 3, 2004, for PCT Appl. No. PCT/US03/31471.
PCT Search Report dated Jan. 23, 2003, for corresponding PCT application number PCT/US02/30825.
Database CHEMCATS 'Online (Feb. 11, 2002), Interbioscreen Compound Library:2002:3027027, XP002220645.
Database CHEMCATS ‘Online’ (Jan. 21, 2002), Ambinter: Exploratory Library: 2002:2845045, 2002: XP00222646.
Database CHEMCATS ‘Online’ (Jan. 21, 2002), Ambinter: Exploratory Library: 2002:1552297, XP002220647.
Database CHEMCATS ‘Online’ (Jan. 15, 2002), Bionet Research: 2001:2494341, 2001:2494321, XP002220648.
Database CHEMCATS ‘Online’ (Jul. 1, 2001), Compo
Averill Kristin M.
Dodd John H.
Heintzelman Geoffrey R.
Ortho-McNeil Pharmaceutical, Inc
Shiao Robert
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