Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-27
1999-01-12
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514374, 514378, 514397, 548202, 548208, 548238, 548247, 5483144, A61K 31415, A61K 3141, A61K 3142, C07D27506, C07D27720, C07D26106
Patent
active
058590358
ABSTRACT:
The present invention is directed to compounds which inhibit famesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting famesyl-protein transferase and the famesyl of the oncogene protein Ras.
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patent: 4977176 (1990-12-01), Amstutz et al.
patent: 5021434 (1991-06-01), Strehlke et al.
patent: 5140034 (1992-08-01), Baker et al.
Anthony Neville J.
Gomez Robert P.
Young Steven D.
Daniel Mark R.
Higel Floyd D.
Merck & Co. , Inc.
Muthard David A.
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