Arylglycinamide derivatives, processes for the manufacture there

Details Arylglycinamide derivatives, processes for the manufacture there Arylglycinamide derivatives, processes for the manufacture there

1996-07-30

1998-01-20

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544130, 544393, 544400, 546 20, 546118, 546191, 546194, 546199, 546208, 546210, 546224, 546225, 546234, A61K 31495, C07D29515

Patent

active

057101558

ABSTRACT:
The invention relates to new arylglycinamide derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and Ar have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokin (tachykinin) antagonists.

REFERENCES:
patent: 3518274 (1970-06-01), Strycker
patent: 3862946 (1975-01-01), Havera
patent: 3906100 (1975-09-01), Havera
patent: 5434158 (1995-07-01), Shah
Chemical Abstracts, vol. 68, No. 3, p. No. 5717, Abstract No. 59230g (1968).
Chemical Abstracts, vol. 11, No. 13, p. No. 7, Abstract No. 54228t (1972).
K. Nagarajan et al., "A Novel Displacement Reaction on a .alpha.-Chlorodiphenylacetamides", Tetrahedron Letters, 15, pp. 1387-1390)1967.

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