Arylcyclopropylcarboxylic amides as potassium channel openers

Details Arylcyclopropylcarboxylic amides as potassium channel openers Arylcyclopropylcarboxylic amides as potassium channel openers

2006-12-05

2006-12-05

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S357000, C514S429000, C514S468000, C514S620000, C544S169000, C546S312000, C548S567000, C549S469000, C564S164000

Reexamination Certificate

active

07144881

ABSTRACT:
The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula Iwherein R, R1, R2, R3, R4, R5, R6and R7are as defined in the specification, or a nontoxic pharmaceutically acceptable salt, solvate or hydrate thereof which are openers or activators of KCNQ potassium channels. The present invention also provides pharmaceutical compositions comprising said arylcyclopropylcarboxylic amides and to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine or a migraine attack, bipolar disorders, epilepsy, acute and chronic pain and anxiety.

REFERENCES:
patent: 4927838 (1990-05-01), Guthrie et al.
patent: 6046239 (2000-04-01), Lennox et al.
patent: 6413995 (2002-07-01), Hasegawa et al.
patent: 810220 (1997-12-01), None
patent: 45-14291 (1970-05-01), None
patent: 2-138159 (1990-05-01), None
patent: 00/07993 (2000-02-01), None
patent: 00/42013 (2000-07-01), None
patent: 01/10380 (2001-02-01), None
patent: 01/10381 (2001-02-01), None
Valentine Gribkoff, The therapeutic potentila of neuronal KCNQ channel modulaters; Central & Peripheral Nervous System; Review; Expert Opinion Therapeutic Targets, 2003: pp. 737-748.
Wang, S., et al. “KCNQ2 and KCNQ3 Potassium Channel Subunits: Modular Correlates of the M-Channel”,Science, pp. 282, 1890-1893 (1998).

Affiliated with

Also associated with

Rating

Arylcyclopropylcarboxylic amides as potassium channel openers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Arylcyclopropylcarboxylic amides as potassium channel openers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylcyclopropylcarboxylic amides as potassium channel openers will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3714884